Trichloroacetyl chloride
Trichloroacetyl chloride structure
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Common Name | Trichloroacetyl chloride | ||
|---|---|---|---|---|
| CAS Number | 76-02-8 | Molecular Weight | 181.833 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 118.0±0.0 °C at 760 mmHg | |
| Molecular Formula | C2Cl4O | Melting Point | -57 °C | |
| MSDS | Chinese USA | Flash Point | 31.0±26.5 °C | |
| Symbol |
GHS05, GHS06 |
Signal Word | Danger | |
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Enantioselective synthesis of dihydro-1H-benzindoles.
J. Org. Chem. 78(7) , 3379-83, (2013) The first examples of dihydro-1H-benzindoles by enantioselective γ-lactamization reaction of naphthyl sulfilimines with trichloroacetyl chloride in the presence of ZnCu as catalyst (≥98:2 er and 65-80% yields) are described. Products are obtained by [3,3]-sig... |
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Synthesis of 3-alkylbenzoxazolones from N-alkyl-N-arylhydroxylamines by contiguous O-trichloroacetylation, trichloroacetoxy ortho-shift, and cyclization sequence.
J. Org. Chem. 78(23) , 11935-47, (2013) Benzoxazolone pharmacophore is present in clinical pharmaceuticals, drug candidates, and many compounds having a wide spectrum of biological activities. The methods available for the synthesis of benzoxazolones have limited diversity due to problems in access... |
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Interindividual variability in P450-dependent generation of neoantigens in halothane hepatitis.
Chem. Biol. Interact. 116(1-2) , 123-41, (1998) Halothane hepatitis occurs because susceptible patients mount immune responses to trifluoroacetylated protein antigens, formed following cytochrome P450-mediated bioactivation of halothane to trifluoroacetyl chloride. In the present study, an in vitro approac... |
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Synthesis of 1,4-dichloro-1,3-butadienes by rhodium complex catalyzed reaction of terminal alkynes with trichloroacetyl chloride.
J. Org. Chem. 74(24) , 9433-9, (2009) Chlorinative dimerization of terminal alkynes with trichloroacetyl chloride as chlorine donor proceeds in the presence of rhodium catalysts to give (Z,Z)-1,4-dichloro-1,3-butadienes stereoselectively. Ligand screening has revealed that reactions using sterica... |
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Developmental toxicity of trichloroethylene, tetrachloroethylene and four of their metabolites in rat whole embryo culture.
Arch. Toxicol. 70(2) , 71-82, (1995) The embryotoxicity of trichloroethylene (TRI), tetrachloroethylene (PER), and of four of their oxidative metabolites i.e. trichloroacetic acid, dichloroacetic acid, chloral hydrate, and trichloroacetyl chloride, was studied in vitro, using the rat whole embry... |
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Mutagenicity of dichloroacetylene and its degradation products trichloroacetyl chloride, trichloroacryloyl chloride and hexachlorobutadiene.
Mutat. Res. 117(1-2) , 21-9, (1983) Dichloroacetylene (DCA) is a highly reactive compound that decomposes rapidly in contact with air into a series of chlorinated aliphatic hydrocarbons (e.g., phosgene, trichloroacetyl chloride, trichloroacryloyl chloride and hexachlorobutadiene). Experiments w... |
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Photochemical reaction monitoring by ultra-violet spectrophotometry.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 58(13) , 2925-30, (2002) Within the framework of the monitoring of the trichloroacetylchloride (TCAC) photosynthesis, ultra-violet (UV) spectrophotometry is proposed as a simple and rapid tool allowing, in real time, the control of the process efficiency. A good correlation has been ... |
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Trichloroacetylation of some cyclic enamines.
Chem. Pharm. Bull. 51(4) , 444-7, (2003) The pyrrolidine and morpholine enamines of cyclic ketones such as cyclohexanone and cyclopentanone were successfully diacetylated at alpha- and alpha'-positions with trichloroacetyl chloride using zinc catalyst. Morpholine enamines of the cyclic ketones gave ... |