Clorgyline hydrochloride
Clorgyline hydrochloride structure
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Common Name | Clorgyline hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 17780-75-5 | Molecular Weight | 308.631 | |
| Density | N/A | Boiling Point | 361.3ºC at 760mmHg | |
| Molecular Formula | C13H16Cl3NO | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 172.3ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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The natural hallucinogen 5-MeO-DMT, component of Ayahuasca, disrupts cortical function in rats: reversal by antipsychotic drugs.
Int. J. Neuropsychopharmacol. 17(8) , 1269-82, (2014) 5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a natural hallucinogen component of Ayahuasca, an Amazonian beverage traditionally used for ritual, religious and healing purposes that is being increasingly used for recreational purposes in US and Europe. 5MeO... |
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Inhibition of semicarbazide-sensitive amine oxidase attenuates myocardial ischemia-reperfusion injury in an in vivo rat model.
Leuk. Res. 88 , 302-6, (2011) This study tested the hypothesis that the inhibition of semicarbazide-sensitive amine oxidase (SSAO) after ischemia could attenuate myocardial ischemia-reperfusion (I/R) injury.Anesthetized male Sprague-Dawley rats underwent myocardial I/R injury. Saline, sem... |
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The role of MAO-A and MAO-B in the metabolic degradation of noradrenaline in human arteries.
J. Auton. Pharmacol. 18 , 123-128, (1998) 1. Segments of human cystic, gastric and ileocolic arteries were obtained from patients undergoing surgery. 2. Segments of arterial tissues, the noradrenaline content of which ranged between 0.27 and 0.52 microg g(-1), were incubated with 0.1 micromol l(-1) [... |
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Comparison of Monoamine Oxidase Inhibitors in Decreasing Production of the Autotoxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde in PC12 Cells.
J. Pharmacol. Exp. Ther. 356 , 483-92, (2016) According to the catecholaldehyde hypothesis, the toxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde (DOPAL) contributes to the loss of nigrostriatal dopaminergic neurons in Parkinson's disease. Monoamine oxidase-A (MAO-A) catalyzes the conversion of i... |
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Species-dependent differences in monoamine oxidase A and B-catalyzed oxidation of various C4 substituted 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridinyl derivatives.
J. Pharmacol. Exp. Ther. 291 , 856, (1999) In an attempt to provide a better understanding of the scope and limitations of animal models used in some drug development programs and to further our understanding of potential metabolic bioactivation reactions, we have undertaken studies to profile the mon... |
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Determination of regions important for monoamine oxidase (MAO) A and B substrate and inhibitor selectivities.
J. Neural Transm. Gen. Sect. 52 , 1-8, (1998) MAO-A and -B are defined by their substrate and inhibitor preferences. To determine which regions of the isoenzymes confer these preferences, we have constructed six chimeric MAO enzymes by reciprocally exchanging corresponding N-terminal, C-terminal, and int... |
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Discovery of 3-Hydroxy-3-phenacyloxindole Analogues of Isatin as Potential Monoamine Oxidase Inhibitors.
ChemMedChem 11 , 119-32, (2016) A series of 3-hydroxy-3-phenacyloxindole analogues of isatin were designed, synthesized, and evaluated in vitro for their inhibitory activity toward monoamine oxidase (MAO) A and B. Most of the synthesized compounds proved to be potent and selective inhibitor... |
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(Thiazol-2-yl)hydrazone derivatives from acetylpyridines as dual inhibitors of MAO and AChE: synthesis, biological evaluation and molecular modeling studies.
J. Enzyme Inhib. Med. Chem. 30 , 908-19, (2015) Several (thiazol-2-yl)hydrazone derivatives from 2-, 3- and 4-acetylpyridine were synthesized and tested against human monoamine oxidase (hMAO) A and B enzymes. Most of them had an inhibitory effect in the low micromolar/high nanomolar range, being derivative... |