3-Chloroaniline

3-Chloroaniline Structure
3-Chloroaniline structure
Common Name 3-Chloroaniline
CAS Number 108-42-9 Molecular Weight 127.572
Density 1.2±0.1 g/cm3 Boiling Point 227.8±13.0 °C at 760 mmHg
Molecular Formula C6H6ClN Melting Point −11-−9 °C(lit.)
MSDS Chinese USA Flash Point 123.9±0.0 °C
Symbol GHS06 GHS08 GHS09
GHS06, GHS08, GHS09
Signal Word Danger

cIEF for rapid pKa determination of small molecules: a proof of concept.

Eur. J. Pharm. Sci. 63 , 14-21, (2014)

A capillary isoelectric focusing (cIEF) method was developed for the determination of the ionization constants (pKa) of small molecules. Two approaches used to decrease the electroosmotic flow (EOF) were compared: (i) a hydroxypropylcellulose (HPC) coated cap...

Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).

J. Med. Chem. 48 , 3269-79, (2005)

Growing interest in the use of both the logarithm of the partition coefficient of the neutral species in the alkane/water system (log P(N)(alk)) and the difference between log P(N)(oct) (the logarithm of the partition coefficient of the neutral species in the...

QSAR study on permeability of hydrophobic compounds with artificial membranes.

Bioorg. Med. Chem. 15 , 3756-67, (2007)

We previously reported a classical quantitative structure-activity relationship (QSAR) equation for permeability coefficients (P(app-pampa)) by parallel artificial membrane permeation assay (PAMPA) of structurally diverse compounds with simple physicochemical...

Dissipation of triclosan, triclocarban, carbamazepine and naproxen in agricultural soil following surface or sub-surface application of dewatered municipal biosolids.

Sci. Total Environ. 512-513 , 480-8, (2015)

In many jurisdictions land application of municipal biosolids is a valued source of nutrients for crop production. The practice must be managed to ensure that crops and adjacent water are not subject to contamination by pharmaceuticals or other organic contam...

Biodegradation of 2-chloroaniline, 3-chloroaniline, and 4-chloroaniline by a novel strain Delftia tsuruhatensis H1.

J. Hazard. Mater. 179(1-3) , 875-82, (2010)

A new strain Delftia tsuruhatensis H1 able to degrade several chloroanilines (CAs) as individual compounds or a mixture was isolated from a CA-degrading mixed bacterial culture. The isolated strain could completely degrade 3-CA and 4-CA as growth substrates, ...

Two-step hollow fiber-based, liquid-phase microextraction combined with high-performance liquid chromatography: a new approach to determination of aromatic amines in water.

J. Chromatogr. A. 1082(2) , 136-42, (2005)

A novel method for the extraction of aromatic amines present in water samples is produced here coupling two-step liquid-phase microextraction with high performance liquid chromatography by using a monolithic column. The hydrophobic porous polypropylene membra...

In vivo and in vitro nephrotoxicity of aniline and its monochlorophenyl derivatives in the Fischer 344 rat.

Toxicology 38(3) , 269-83, (1986)

Aniline (A) and its monochlorophenyl derivatives (2-CA, 3-CA and 4-CA) are widely-used chemical intermediates. In the present study, the in vivo and in vitro nephrotoxic potential of these compounds was assessed in Fischer 344 rats. In the in vivo experiments...

Bioaugmentation of activated sludge towards 3-chloroaniline removal with a mixed bacterial population carrying a degradative plasmid

Bioresour. Technol. 100(12) , 2902-9, (2009)

A bioaugmentation approach combining several strategies was applied to achieve degradation of 3-chloroaniline (3CA) in semicontinuous activated sludge reactors. In a first step, a 3CA-degrading Comamonas testosteroni strain carrying the degradative plasmid pN...

The utilization of aniline, chlorinated aniline, and aniline blue as the only source of nitrogen by fungi in water.

Water Res. 35(5) , 1219-24, (2001)

The ability of fungi to degrade aniline and its derivatives in water is reported. Several fungi are able to degrade aniline and its derivatives as a sole nitrogen, carbon and energy source. Some of these fungi were obtained from activated sludge by enrichment...

Biotransformation of monochloroanilines in guppy, Poecilia reticulata.

Xenobiotica 24(1) , 59-69, (1994)

1. Guppies (Poecilia reticulata) were exposed for 96 h to 4-chloroaniline (4CA), 3-chloroaniline (3CA) and 2-chloroaniline (2CA) in a static exposure system. 4-Chloroacetanilide (N4CA), 3-chloroacetanilide (N3CA), and 2-chloroacetanilide (N2CA) were identifie...