4-Fluoroaniline
4-Fluoroaniline structure
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Common Name | 4-Fluoroaniline | ||
|---|---|---|---|---|
| CAS Number | 371-40-4 | Molecular Weight | 111.117 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 188.9±13.0 °C at 760 mmHg | |
| Molecular Formula | C6H6FN | Melting Point | -1.9 °C | |
| MSDS | Chinese USA | Flash Point | 73.9±0.0 °C | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
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Growth of Thin, Anisotropic, π-Conjugated Molecular Films by Stepwise "Click" Assembly of Molecular Building Blocks: Characterizing Reaction Yield, Surface Coverage, and Film Thickness versus Addition Step Number.
J. Am. Chem. Soc. 137 , 8819-28, (2015) We report the systematic characterization of anisotropic, π-conjugated oligophenyleneimine (OPI) films synthesized using stepwise imine condensation, or "click" chemistry. Film synthesis began with a self-assembled monolayer (SAM) of 4-formylthiophenol or 4-a... |
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Biopartitioning micellar chromatography to predict mutagenicity of aromatic amines.
Eur. J. Med. Chem. 42 , 1396-402, (2007) Mutagenicity is a toxicity endpoint associated with the chronic exposure to chemicals. Aromatic amines have considerable industrial and environmental importance due to their widespread use in industry and their mutagenic capacity. Biopartitioning micellar chr... |
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The many roles for fluorine in medicinal chemistry.
J. Med. Chem. 51 , 4359-69, (2008)
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Potential of neurotoxicity after a single oral dose of 4-bromo-, 4-chloro-, 4-fluoro- or 4-iodoaniline in rats.
J. Appl. Toxicol. 23(5) , 315-22, (2003) The potential for neurotoxicity after a single oral dose of four halogenated aniline derivatives--4-bromoaniline (4-BA), 4-chloroaniline (4-CA), 4- fluoroaniline (4-FA) and 4-iodoaniline (4-IA)--was given to rats was investigated at or near the lethal dosage ... |
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The effect of varying halogen substituent patterns on the cytochrome P450 catalysed dehalogenation of 4-halogenated anilines to 4-aminophenol metabolites.
Biochem. Pharmacol. 49(9) , 1235-48, (1995) The cytochrome P450 catalysed biotransformation of 4-halogenated anilines was studied in vitro with special emphasis on the dehalogenation to 4-aminophenol metabolites. The results demonstrated that a fluorine substituent at the C4 position was more easily el... |
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Theoretical Raman and infrared spectra, and vibrational assignment for para-halogenoanilines: DFT study.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 68(3) , 948-55, (2007) The theoretical IR and Raman spectra of para-halogenoanilines, 4-XC(6)H(4)NH(2) (X=F, Cl and Br) were calculated by using the density functional B3LYP method with the 6-311++G(df,pd) basis set. The theoretical spectra show very good agreement with experiment.... |
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Metabolism and Disposition of Cabozantinib in Healthy Male Volunteers and Pharmacologic Characterization of Its Major Metabolites.
Drug Metab. Dispos. 43 , 1190-207, (2015) Metabolism and excretion of cabozantinib, an oral inhibitor of receptor tyrosine kinases, was studied in 8 healthy male volunteers after a single oral dose of 175 mg cabozantinib l-malate containing (14)C-cabozantinib (100 µCi/subject). Total mean radioactivi... |
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Study on the regioselectivity and mechanism of the aromatic hydroxylation of monofluoroanilines.
Chem. Biol. Interact. 85(2-3) , 151-72, (1992) The in vitro and in vivo metabolism of monofluoroanilines was investigated. Special attention was focused on the regioselectivity of the aromatic hydroxylation by cytochromes P-450 and the mechanism by which this reaction might proceed. The results clearly de... |
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Aerobic degradation study of three fluoroanilines and microbial community analysis: the effects of increased fluorine substitution.
Biodegradation 26(1) , 1-14, (2015) The fate of fluorinated compounds in the environment, especially polyfluorinated aromatics, is a matter of great concern. In this work, 4-Fluoroaniline (4-FA), 2,4-Difluoroanilines (2,4-DFA), and 2,3,4-Trifluoroanilines (2,3,4-TFA), were chosen as the target ... |
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Luminescent monocyclometalated cationic gold(III) complexes: synthesis, photophysical characterization and catalytic investigations.
Dalton Trans. 43(31) , 11959-72, (2014) Stable, luminescent, and cationic monocyclometalated gold(iii) monoaryl complexes of the type [(ppy)Au(FMes)(L)](+)[OTf](-) [L = 4-phenylpyridine (), quinoline (), 4-fluoroaniline (), P(OMe)3 (), PPh3 ()], bearing different ancillary ligands, synthesized star... |