Methyl (2E)-3-(2,5-dihydroxyphenyl)acrylate
Methyl (2E)-3-(2,5-dihydroxyphenyl)acrylate structure
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Common Name | Methyl (2E)-3-(2,5-dihydroxyphenyl)acrylate | ||
|---|---|---|---|---|
| CAS Number | 63177-57-1 | Molecular Weight | 194.184 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 400.7±35.0 °C at 760 mmHg | |
| Molecular Formula | C10H10O4 | Melting Point | 178-180°C | |
| MSDS | Chinese USA | Flash Point | 163.3±19.4 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Direct inhibition of the hexose transporter GLUT1 by tyrosine kinase inhibitors.
Biochemistry 40(3) , 777-90, (2001) The facilitative hexose transporter GLUT1 is a multifunctional protein that transports hexoses and dehydroascorbic acid, the oxidized form of vitamin C, and interacts with several molecules structurally unrelated to the transported substrates. Here we analyze... |
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Mechanism of topoisomerase II inhibition by staurosporine and other protein kinase inhibitors.
J. Biol. Chem. 271(42) , 26418-23, (1996) Topoisomerase II is an essential enzyme for proliferation of eukaryotic cells. It is also a target for many antineoplastic drugs that promote stabilization of covalent complexes between topoisomerase II and DNA. Topoisomerase II and protein kinases both catal... |
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Signal pathways that transduce growth factor-stimulated mitogenesis in bone cells.
Bone 23(1) , 17-26, (1998) This investigation examined which signal pathways are of relevance in growth factor-stimulated bone cell mitogenesis. Platelet-derived growth factor (PDGF) and insulin-like growth factor-II (IGF-II) were potent mitogens for both the MG-63 osteoblast cell line... |
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Suppression of tyrosine kinase activity inhibits [3H]thymidine uptake in cultured human pituitary tumor cells.
J. Clin. Endocrinol. Metab. 82(7) , 2143-7, (1997) Tyrosine kinases are involved in the phosphorylation of proteins that regulate cell growth and proliferation. The mitogenic effect of several growth factors requires tyrosine kinase activity of their receptors. The effect of inhibition of tyrosine kinase acti... |
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Regulation of the renal Na-HCO3 cotransporter: IX. Modulation by insulin, epidermal growth factor and carbachol.
Regul. Pept. 77(1-3) , 155-61, (1998) To examine the role of tyrosine kinase (TK) on basolateral membrane (BLM) transport, we looked for the presence of TK activity in these membranes and showed that the synthetic substrate for TK, poly [Glu80 Na, Tyr20] caused a three-fold increase in tyrosine p... |
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Tyrosine kinase inhibitor, methyl 2,5-dihydromethylcinnimate, induces PML nuclear body formation and apoptosis in tumor cells.
Exp. Cell Res. 313(13) , 2753-65, (2007) Promyelocytic leukemia (PML) nuclear bodies (PML-NBs) are the nuclear structure consisting of various proteins such as PML, SUMO-1, and p53. PML-NBs are implicated in the regulation of tumor suppression, antiviral responses, and apoptosis. In this study, we s... |
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Regulation of renal Na-HCO3 cotransporter: VIII. Mechanism Of stimulatory effect of respiratory acidosis.
J. Membr. Biol. 162(3) , 201-8, (1998) We examined the effect of respiratory acidosis on the Na-HCO3 cotransporter activity in primary cultures of the proximal tubule of the rabbit exposed to 10% CO2 for 5 min, 2, 4, 24 and 48 hr. Cells exposed to 10% CO2 showed a significant increase in Na-HCO3 c... |
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Differential effects of the tyrosine kinase inhibitors on collagen type 1-induced platelet aggregation and adhesion to this protein.
Thromb. Res. 86(4) , 287-99, (1997) Herbimycin A, lavendustin A, and methyl 2,5-dihydroxycinnamate were used to study the role of protein tyrosine kinases in collagen-platelet interaction. All three compounds produced a concentration dependent inhibition of platelet aggregation induced by colla... |
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Attenuation of endothelin-1-induced calcium response by tyrosine kinase inhibitors in vascular smooth muscle cells.
Am. J. Physiol. 270(6 Pt 1) , C1825-33, (1996) Although tyrosine kinases play an important role in cell growth and have been implicated in regulation of smooth muscle contraction, their role in agonist-induced myoplasmic Ca2+ responses is unclear. We examined effects of the tyrosine kinase inhibitors geni... |
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Inhibition of cytokine-inducible nitric oxide synthase in rat microglia and murine macrophages by methyl-2,5-dihydroxycinnamate.
Neurochem. Int. 29(1) , 83-7, (1996) Microglial cells are resident macrophages in the central nervous system (CNS) which serve specific functions in the defence of the CNS against microorganisms, the removal of tissue debris in neurodegenerative diseases or during normal development, and in auto... |