Antimicrobial Agents and Chemotherapy 2008-11-01

Characterization of TolC efflux pump proteins from Pasteurella multocida.

Tamas Hatfaludi, Keith Al-Hasani, Michelle Dunstone, John Boyce, Ben Adler

Index: Antimicrob. Agents Chemother. 52 , 4166-71, (2008)

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Abstract

Two TolC homologs, PM0527 and PM1980, were identified for Pasteurella multocida. A pm0527 mutant displayed increased susceptibility to a range of chemicals, including rifampin (512-fold) and acridine orange (128-fold). A pm1980 mutant showed increased susceptibility to rifampin, ceftazidime, and vancomycin.