Journal of Natural Products 2008-05-01

alpha-Glucosidase inhibitory activity of triterpenoids from Cichorium intybus.

Atta-ur-Rahman, Seema Zareen, M Iqbal Choudhary, M Nadeem Akhtar, Shamsun Nahar Khan

Index: J. Nat. Prod. 71 , 910-3, (2008)

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Abstract

Two new triterpenoids, 18alpha,19beta-20(30)-taraxasten-3beta,21alpha-diol (cichoridiol) (1) and 17-epi-methyl-6-hydroxyangolensate (intybusoloid) (2), were obtained from the methanolic extract of seeds of Cichorium intybus along with 11 known compounds, lupeol (3), friedelin (4), beta-sitosterol (5), stigmasterol (6), betulinic acid (7), betulin (8), betulinaldehyde (9), syringic acid (10), vanillic acid (11) 6,7-dihydroxycoumarin (12), and methyl-alpha-D-galactopyranoside (13). Compounds 1, 1a, and 11 showed a good alpha-glucosidase inhibitory activity.