Synthesis of Trifluoromethyl Ketones by Palladium-Catalyzed Cross-Coupling Reaction of Phenyl Trifluoroacetate with Organoboron Compounds.

R Kakino, I Shimizu, A Yamamoto

Index: Kakino; Shimizu; Yamamoto Bulletin of the Chemical Society of Japan, 2001 , vol. 74, # 2 p. 371 - 376

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Citation Number: 101

Abstract

Cross-coupling reaction of aryl trifluoroacetates with organoboron compounds catalyzed by palladium complexes gives trifluoromethyl ketones in moderate to excellent yields under mild conditions. The catalytic process has been designed on the basis of fundamental studies dealing with oxidative addition of phenyl trifluoroacetate to a Pd (0) complex to give a (phenoxo)(trifluoroacetyl) palladium (II) complex and its subsequent reaction with ...