Fraxin
Fraxin structure
|
Common Name | Fraxin | ||
|---|---|---|---|---|
| CAS Number | 524-30-1 | Molecular Weight | 370.308 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 722.2±60.0 °C at 760 mmHg | |
| Molecular Formula | C16H18O10 | Melting Point | 205-208ºC | |
| MSDS | Chinese USA | Flash Point | 267.1±26.4 °C | |
Use of FraxinFraxin isolated from Acer tegmentosum, F. ornus or A. hippocastanum, is a glucoside of fraxetin and reported to exert potent anti-oxidative stress action[1], anti-inflammatory and antimetastatic properties. Fraxin shows its antioxidative effect through inhibition of cyclo AMP phosphodiesterase enzyme[2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | fraxin |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Fraxin isolated from Acer tegmentosum, F. ornus or A. hippocastanum, is a glucoside of fraxetin and reported to exert potent anti-oxidative stress action[1], anti-inflammatory and antimetastatic properties. Fraxin shows its antioxidative effect through inhibition of cyclo AMP phosphodiesterase enzyme[2]. |
|---|---|
| Related Catalog | |
| Target |
Cyclo AMP phosphodiesterase enzyme[2]. |
| In Vitro | Fraxin (100 μM) is non-cytotoxic on Hep G2 cells. Fraxin at non-cytotoxic concentrations significantly decreases the t-BHP-induced ROS generation in a dose-dependent manner[1]. Fraxin (0.5 mM) shows free radical scavenging effect at high concentration and cell protective effect against H2O2-mediated oxidative stress[2]. |
| In Vivo | Fraxin (50 mg/kg, p.o.) significantly blocks the CCl4-induced elevation of ALT and AST. Fraxin (10 and 50 mg/kg, p.o.) significantly reduces the GSSG levels (1.7±0.3 and 1.5±0.2 nM/g liver, respectively) compared with the GSSG levels of the CCl4-treated group[1]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 722.2±60.0 °C at 760 mmHg |
| Melting Point | 205-208ºC |
| Molecular Formula | C16H18O10 |
| Molecular Weight | 370.308 |
| Flash Point | 267.1±26.4 °C |
| Exact Mass | 370.089996 |
| PSA | 159.05000 |
| LogP | -1.93 |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
| Index of Refraction | 1.664 |
| InChIKey | CRSFLLTWRCYNNX-QBNNUVSCSA-N |
| SMILES | COc1cc2ccc(=O)oc2c(OC2OC(CO)C(O)C(O)C2O)c1O |
| Storage condition | 2-8°C |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Hazard Codes | Xi |
|---|---|
| RIDADR | NONH for all modes of transport |
| RTECS | DJ3091000 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 0 | |
|---|---|
| DownStream 1 | |
CAS#:574-84-5This table lists relevant public references with title, journal and publication metadata for this compound.
|
Screening for novel quorum-sensing inhibitors to interfere with the formation of Pseudomonas aeruginosa biofilm.
J. Med. Microbiol. 60(Pt 12) , 1827-34, (2011) The objective of this study was to screen for novel quorum-sensing inhibitors (QSIs) from traditional Chinese medicines (TCMs) that inhibit bacterial biofilm formation. Six of 46 active components fou... |
|
|
[Studies on chemical constituents from stem barks of Fraxinus paxiana].
Zhongguo Zhong Yao Za Zhi 33(16) , 1990-3, (2008) To investigate the chemical constituents of Fraxinus paxiana.The chemical constituents were isolated and purified by chromatographic techniques and the structures of the compounds were identified with... |
|
|
[Coumarins from branch of Fraxinus sieboldiana and their antioxidative activity].
Zhongguo Zhong Yao Za Zhi 33(14) , 1708-10, (2008) To investigate the chemical constituents from the branch of Fraxinus sieboldiana, and evaluate their antioxidative activity.The chemical constituents were isolated and purified by chromatographic tech... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
|
Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
|
|
Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
|
|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
|
|
Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
|
|
Name: Minimum inhibitory concentration against Escherichia coli (CECT405)
Source: ChEMBL
Target: Escherichia coli
External Id: CHEMBL678656
|
|
Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
|
|
Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity
|
|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
|
|
Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN
|
|
Name: Absorbance-based primary biochemical high throughput screening assay to identify acti...
Source: The Scripps Research Institute Molecular Screening Center
Target: caspase-3 preproprotein [Homo sapiens]
External Id: PROCASPASE3_ACT_EPIABS_1536_1X%ACT PRUN
|
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 7,8-Dihydroxy-6-methoxycoumarin-8-b-D-glucoside |
| 7-Hydroxy-6-methoxy-2-oxo-2H-chromen-8-yl β-D-glucopyranoside |
| 8-(Glucosyloxy)-6-methoxyumbelliferone |
| UNII-V7M270Y072 |
| 7-Hydroxy-6-méthoxy-8-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyméthyl)tétrahydro-2H-pyran-2-yl]oxy}-2H-chromén-2-one |
| 7-Hydroxy-6-methoxy-8-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-2H-chromen-2-on |
| 8-(β-D-Glucopyranosyloxy)-7-hydroxy-6-methoxy-2H-1-benzopyran-2-one |
| Fraxin |
| 8-(b-D-Glucopyranosyloxy)-7-hydroxy-6-methoxy-2H-1-benzopyran-2-one |
| Fraxoside |
| Fraxetin-8-O-glucoside |
| Fraxetin-8-glucoside |
| Paviin |
| 7-Hydroxy-6-methoxy-2-oxo-2H-chromen-8-yl-β-D-glucopyranoside |
| Fraxetol 8-glucoside |
| 7-Hydroxy-6-methoxy-8-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-2H-chromen-2-one |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the CAS number of fraxin? |
| A: CAS number of fraxin is 524-30-1. |
| Q: What is the polar surface area (PSA) of fraxin? |
| A: Polar surface area (PSA) of fraxin is 159.05000. |
| Q: What is the SMILES notation of fraxin? |
| A: SMILES notation of fraxin is COc1cc2ccc(=O)oc2c(OC2OC(CO)C(O)C(O)C2O)c1O. |
| Q: What is the English name of fraxin? |
| A: The English name of fraxin is fraxin. |
| Q: What is the molecular formula of fraxin? |
| A: Molecular formula of fraxin is C16H18O10. |
| Q: What is the boiling point of fraxin? |
| A: Boiling point of fraxin is 722.2±60.0 °C at 760 mmHg. |
| Q: What are the storage conditions for fraxin? |
| A: Storage conditions for fraxin: 2-8°C. |
| Q: What are the uses of fraxin? |
| A: Main uses of fraxin: Fraxin isolated from Acer tegmentosum, F. ornus or A. hippocastanum, is a glucoside of fraxetin and reported to exert potent anti-oxidative stress action[1], anti-inflammatory and antimetastatic properties. Fraxin shows its antioxidative effect through inhibition of cyclo AMP phosphodiesterase enzyme[2]. |
| Q: What is the LogP of fraxin? |
| A: LogP of fraxin is -1.93. |
| Q: What is the molecular weight of fraxin? |
| A: Molecular weight of fraxin is 370.308. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| naturewill |