Indole-2-carboxylic acid

Modify Date: 2025-08-22 13:01:17

Indole-2-carboxylic acid structure	Common Name	Indole-2-carboxylic acid
	CAS Number	1477-50-5	Molecular Weight	161.157
	Density	1.4±0.1 g/cm3	Boiling Point	419.6±18.0 °C at 760 mmHg
	Molecular Formula	C₉H₇NO₂	Melting Point	202-206 °C(lit.)
	MSDS	USA	Flash Point	207.6±21.2 °C

Use of Indole-2-carboxylic acid

Indole-2-carboxylic acid is a strong inhibitor of lipid peroxidation. Indole-2-carboxylic acid (I2CA) specifically and competitively inhibits the potentiation by glycine of NMDA-gated current[1][2].

Name	Indole-2-carboxylic acid
Synonym	More Synonyms

Description	Indole-2-carboxylic acid is a strong inhibitor of lipid peroxidation. Indole-2-carboxylic acid (I2CA) specifically and competitively inhibits the potentiation by glycine of NMDA-gated current[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
Target	Human Endogenous Metabolite
References	[1]. 2-Indolecarboxylic acid. [2]. J E Huettner, et al. Indole-2-carboxylic Acid: A Competitive Antagonist of Potentiation by Glycine at the NMDA Receptor. Science. 1989 Mar 24;243(4898):1611-3.

Density	1.4±0.1 g/cm3
Boiling Point	419.6±18.0 °C at 760 mmHg
Melting Point	202-206 °C(lit.)
Molecular Formula	C₉H₇NO₂
Molecular Weight	161.157
Flash Point	207.6±21.2 °C
Exact Mass	161.047684
PSA	53.09000
LogP	2.31
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.726
InChIKey	HCUARRIEZVDMPT-UHFFFAOYSA-N
SMILES	O=C(O)c1cc2ccccc2[nH]1

Indole-2-carboxylic acid MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;Xn: Harmful;
Risk Phrases	R36/37/38
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	NK7882812
HS Code	29339990

Precursor 10
CAS#:3770-50-1 Ethyl indole-2-... CAS#:19005-93-7 indolecarboxaldehyde CAS#:615-43-0 2-Iodoaniline CAS#:127-17-3 Pyruvic acid
CAS#:40899-93-2 1-(benzenesulfo... CAS#:615-36-1 2-Bromoaniline CAS#:58881-41-7 Pyrazino[1,2-a;... CAS#:26340-49-8 2-Iodo-1H-indole
CAS#:124-38-9 Carbon dioxide CAS#:120-72-9 Indole
DownStream 10
CAS#:103476-80-8 (2-PYRROLIDIN-1... CAS#:5055-39-0 1H-Indole-2-car... CAS#:32588-36-6 Indole-2-acetic acid CAS#:14255-18-6 1H-Indole,2-(2-...
CAS#:1485-22-9 1H-Indole-2-met... CAS#:101125-32-0 3-(4-Fluorophen... CAS#:141306-08-3 5-chloro-3-(4-f... CAS#:4264-35-1 1-(1H-Indol-2-y...
CAS#:17537-64-3 1,3-diacetylindole CAS#:703-80-0 3-Acetylindole

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies.

Bioorg. Med. Chem. 17 , 5219-28, (2009)

In the light of known HDAC inhibitors, 33 carboxylic acid derivatives were tested to understand the structural requirements for HDAC inhibition activity. Several modifications were applied to develop ...

In vitro and in vivo assessment of the antioxidant activity of melatonin and related indole derivatives.

Gen. Physiol. Biophys. 21(2) , 153-62, (2002)

Effects of melatonin and some structurally related indole compounds were studied by in vitro methods such as (i) an inhibition of the hyaluronic acid degradation and (ii) a standard lipid peroxidation...

Protonated carbonic acid and reactive intermediates in the acidic decarboxylation of indolecarboxylic acids.

J. Org. Chem. 77(15) , 6505-9, (2012)

Elucidation of the mechanism for decarboxylation of indolecarboxylic acids over a wide range of solution acidity reveals the importance of protonated carbonic acid (PCA) as a reaction intermediate. In...

1H-Indole-2-carboxylic acid

T56 BMJ CVQ

Indole-2-carboxylic acid

2-Carboxyindole

2-Indolecarboxylic acid

MFCD00005611

EINECS 216-030-4

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Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: Indole-2-carboxylic acid
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
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Indole-2-carboxylic acid

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