Integrase-LEDGF/p75 allosteric inhibitor 1

Modify Date: 2024-01-12 10:29:07

Integrase-LEDGF/p75 allosteric inhibitor 1 structure	Common Name	Integrase-LEDGF/p75 allosteric inhibitor 1
	CAS Number	1431738-14-5	Molecular Weight	579.75
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₃H₄₁NO₆S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Integrase-LEDGF/p75 allosteric inhibitor 1

Integrase-LEDGF/p75 allosteric inhibitor 1 (Compound 31h) is an orally active integrase-LEDGF/p75 (IN-LEDGF/p75) allosteric inhibitor. Integrase-LEDGF/p75 allosteric inhibitor 1 inhibits HIV-1 DNA integration and shows antiviral activity with an EC50 of 3.9 nM against HIV-1 recombinant molecular clone NL432[1].

Name	Integrase-LEDGF/p75 allosteric inhibitor 1

Description	Integrase-LEDGF/p75 allosteric inhibitor 1 (Compound 31h) is an orally active integrase-LEDGF/p75 (IN-LEDGF/p75) allosteric inhibitor. Integrase-LEDGF/p75 allosteric inhibitor 1 inhibits HIV-1 DNA integration and shows antiviral activity with an EC50 of 3.9 nM against HIV-1 recombinant molecular clone NL432[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Integrase
Target	EC50: 3.9 nM (NL432)[1]
In Vivo	Integrase-LEDGF/p75 allosteric inhibitor 1 (Compound 31h) has moderate metabolic stability (HLM MS = 59%, RLM MS = 61%), exhibits good clearance (CLt = 6.99 mL/min/kg) and good bioavailability (F = 36%) in rats[1].
References	[1]. Sugiyama S, et al. Discovery of novel integrase-LEDGF/p75 allosteric inhibitors based on a benzene scaffold. Bioorg Med Chem. 2020 Sep 1;28(17):115643.

Molecular Formula	C₃₃H₄₁NO₆S
Molecular Weight	579.75

Integrase-LEDGF/p75 allosteric inhibitor 1

Use of Integrase-LEDGF/p75 allosteric inhibitor 1

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Biological Activity

Chemical & Physical Properties