Cathepsin K inhibitor 3
Modify Date: 2023-01-15 14:03:09
Cathepsin K inhibitor 3 structure
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Common Name | Cathepsin K inhibitor 3 | ||
|---|---|---|---|---|
| CAS Number | 1694638-70-4 | Molecular Weight | 562.65 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H31FN4O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Cathepsin K inhibitor 3Cathepsin K inhibitor 3 (compound 23) is a highly selective cathepsin K inhibitor with an IC50 value of 0.5 nM. Cathepsin K inhibitor 3 has a favorable pharmacokinetic profile and may be used in osteoarthritis (OA) disease studies[1]. |
| Name | Cathepsin K inhibitor 3 |
|---|
| Description | Cathepsin K inhibitor 3 (compound 23) is a highly selective cathepsin K inhibitor with an IC50 value of 0.5 nM. Cathepsin K inhibitor 3 has a favorable pharmacokinetic profile and may be used in osteoarthritis (OA) disease studies[1]. |
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| Related Catalog | |
| Target |
cathepsin K:0.5 nM (IC50) |
| In Vivo | Cathepsin K inhibitor 3 (compound 23) (p.o., 0.03-15 mg/kg, daily, 4 days) results in a significant and dose-dependent reduction in uCTX-I, with an 81% reduction in uCTX-1 levels at 0.3 mg/kg and a slightly more complete reduction at 15 mg/kg in dog[1]. The pharmacokinetic parameters of compound 23 Parameters Cl(mL/min/kg) T1/2(h) %F Rat 13 1 33 Dog 3.1 4.1 38 Rhesus 18.5 2.3 55 |
| Molecular Formula | C30H31FN4O4S |
|---|---|
| Molecular Weight | 562.65 |