KTX-951

Modify Date: 2024-02-04 16:11:09

KTX-951 structure	Common Name	KTX-951
	CAS Number	2573298-36-7	Molecular Weight	850.95
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₆H₅₂F₂N₈O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of KTX-951

KTX-951 is an IRAK4 degrader (DC50=18 nM). KTX-951 (10 mg/kg) shows the oral bioavailability (F%) of 22% in a rat model. KTX-951 has good anticancer potential[1].

Name	KTX-951

Description	KTX-951 is an IRAK4 degrader (DC50=18 nM). KTX-951 (10 mg/kg) shows the oral bioavailability (F%) of 22% in a rat model. KTX-951 has good anticancer potential[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> IRAK Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK
Target	IRAK4[1].
References	[1]. Walker D H, et al. Degraders targeting both IRAK4 and IMiD substrates show combinatorial effects leading to broader activity with durable and complete regressions in MYD88 mutant lymphoma xenografts in vivo. Cancer Research, 2020, 80(16_Supplement): 5222-5222.

Molecular Formula	C₄₆H₅₂F₂N₈O₆
Molecular Weight	850.95