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64208-32-8

64208-32-8 structure
64208-32-8 structure
  • Name: CGP 12177 hydrochloride
  • Chemical Name: 4-[3-(tert-butylamino)-2-hydroxypropoxy]-1,3-dihydrobenzimidazol-2-one,hydrochloride
  • CAS Number: 64208-32-8
  • Molecular Formula: C14H22ClN3O3
  • Molecular Weight: 315.80
  • Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
  • Create Date: 2017-09-22 03:46:13
  • Modify Date: 2025-08-28 18:54:06
  • CGP 12177 ((±)-CGP 12177) hydrochloride is a β Adrenergic Receptor Ligand. CGP 12177 hydrochloride is a high affinity antagonist of β1- and β2-AR. CGP 12177 hydrochloride is also shown to interact, with a lower affinity, with the β3-AR and to exhibit a partial agonist activity on rodent and human β3-AR. CGP 12177 hydrochloride exhibits partial agonist properties for α1-AR in rat pulmonary artery[1].

Name 4-[3-(tert-butylamino)-2-hydroxypropoxy]-1,3-dihydrobenzimidazol-2-one,hydrochloride
Description CGP 12177 ((±)-CGP 12177) hydrochloride is a β Adrenergic Receptor Ligand. CGP 12177 hydrochloride is a high affinity antagonist of β1- and β2-AR. CGP 12177 hydrochloride is also shown to interact, with a lower affinity, with the β3-AR and to exhibit a partial agonist activity on rodent and human β3-AR. CGP 12177 hydrochloride exhibits partial agonist properties for α1-AR in rat pulmonary artery[1].
Related Catalog
Target

Beta-1 adrenergic receptor

Beta-2 adrenergic receptor

Beta-3 adrenergic receptor

α1-adrenergic receptor

References

[1]. Leblais V, et al. Role of alpha-adrenergic receptors in the effect of the beta-adrenergic receptor ligands, CGP 12177, bupranolol, and SR 59230A, on the contraction of rat intrapulmonary artery. J Pharmacol Exp Ther. 2004 Apr;309(1):137-45.  

Molecular Formula C14H22ClN3O3
Molecular Weight 315.80
Exact Mass 315.13500
PSA 90.14000
LogP 2.17690
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