1135278-54-4
1135278-54-4 structure
- Name: CGP 78608 hydrochloride
- Chemical Name: CGP 78608 hydrochloride
- CAS Number: 1135278-54-4
- Molecular Formula: C11H14BrClN3O5P
- Molecular Weight: 414.58
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
- Create Date: 2020-06-01 17:21:58
- Modify Date: 2024-01-09 13:48:38
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CGP 78608 hydrochloride is a highly potent and selective antagonist at the glycine-binding site of the NMDA receptor, with an IC50 of 6 nM. CGP 78608 acts as a potentiator of GluN1/GluN3A-mediated glycine currents, with an estimated EC50 in the low nM range (26.3 nM). Anticonvulsant activity[1][2].
| Name | CGP 78608 hydrochloride |
|---|
| Description | CGP 78608 hydrochloride is a highly potent and selective antagonist at the glycine-binding site of the NMDA receptor, with an IC50 of 6 nM. CGP 78608 acts as a potentiator of GluN1/GluN3A-mediated glycine currents, with an estimated EC50 in the low nM range (26.3 nM). Anticonvulsant activity[1][2]. |
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| Related Catalog | |
| In Vitro | CGP-78608 hydrochloride decreases glycine sensitivity of GluN1/GluN3A receptors through an inter-subunit allosteric effect between GluN1 and GluN3A agonist-binding domain (ABD) sites[2]. CGP 78608 hydrochloride reduces or abolishes ammonia-dependent cGMP synthesis which is a causative factor of ammonia neurotoxicity[3]. |
| In Vivo | CGP-78608 hydrochloride displays potent anticonvulsant effects after i.p. administration in the electroshock-induced convulsions assay in mice[1]. |
| References |
[1]. Catarzi D, et al. Competitive Gly/NMDA receptor antagonists. Curr Top Med Chem. 2006;6(8):809-21. |
| Molecular Formula | C11H14BrClN3O5P |
|---|---|
| Molecular Weight | 414.58 |