6812-87-9

6812-87-9 structure

Name: 12-Hydroxyabieta-8,12-diene-11,14-dione
Chemical Name: Royleanone
CAS Number: 6812-87-9
Molecular Formula: C₂₀H₂₈O₃
Molecular Weight: 316.43
Catalog: Natural product Moss
Create Date: 2018-09-02 16:58:28
Modify Date: 2024-01-03 16:13:47
Royleanone, a diterpenoid isolated from plants, inhibits the proliferation of cancer cells by inducing cell cycle arrest and mitochondria-mediated apoptosis, also inhibits cell migration potential, inhibits mTOR/PI3/AKT signaling pathway in LNCaP prostate cancer cells[1].

Name	Royleanone
Synonyms	1,4-Phenanthrenedione, 4b,5,6,7,8,8a,9,10-octahydro-3-hydroxy-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS)- 12-Hydroxyabieta-8,12-diene-11,14-dione 1-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenan threne-3,4-dione 12-Hydroxy-13-isopropylpodocarpa-8,12-diene-11,14-dione 7α-12-Hydroxy-8,12-abietadiene-11,14-dione

Description	Royleanone, a diterpenoid isolated from plants, inhibits the proliferation of cancer cells by inducing cell cycle arrest and mitochondria-mediated apoptosis, also inhibits cell migration potential, inhibits mTOR/PI3/AKT signaling pathway in LNCaP prostate cancer cells[1].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Target	mTOR/PI3/AKT[1]
In Vitro	Royleanone (0-200 μM; 48 h) 以剂量依赖性方式抑制 LNCaP 癌细胞的活力，IC50 为 12.5 μM[1]。
References	[1]. Wu X, et al. Royleanone diterpenoid exhibits potent anticancer effects in LNCaP human prostate carcinoma cells by inducing mitochondrial mediated apoptosis, cell cycle arrest, suppression of cell migration and downregulation of mTOR/PI3K/AKT signalling pathway. J BUON. 2018 Jul-Aug;23(4):1055-1060.

Hazard Codes	Xi