12-Hydroxyabieta-8,12-diene-11,14-dione
Modify Date: 2024-01-03 16:13:47
12-Hydroxyabieta-8,12-diene-11,14-dione structure
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Common Name | 12-Hydroxyabieta-8,12-diene-11,14-dione | ||
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| CAS Number | 6812-87-9 | Molecular Weight | 316.43 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 426.4±45.0 °C at 760 mmHg | |
| Molecular Formula | C20H28O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 225.8±25.2 °C | |
| Purity | Quantity | Budget | Inquiry |
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Use of 12-Hydroxyabieta-8,12-diene-11,14-dioneRoyleanone, a diterpenoid isolated from plants, inhibits the proliferation of cancer cells by inducing cell cycle arrest and mitochondria-mediated apoptosis, also inhibits cell migration potential, inhibits mTOR/PI3/AKT signaling pathway in LNCaP prostate cancer cells[1]. |
| Name | Royleanone |
|---|---|
| Synonym | More Synonyms |
| Description | Royleanone, a diterpenoid isolated from plants, inhibits the proliferation of cancer cells by inducing cell cycle arrest and mitochondria-mediated apoptosis, also inhibits cell migration potential, inhibits mTOR/PI3/AKT signaling pathway in LNCaP prostate cancer cells[1]. |
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| Related Catalog | |
| Target |
mTOR/PI3/AKT[1] |
| In Vitro | Royleanone (0-200 μM; 48 h) 以剂量依赖性方式抑制 LNCaP 癌细胞的活力，IC50 为 12.5 μM[1]。 |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 426.4±45.0 °C at 760 mmHg |
| Molecular Formula | C20H28O3 |
| Molecular Weight | 316.43 |
| Flash Point | 225.8±25.2 °C |
| Exact Mass | 316.203857 |
| PSA | 54.37000 |
| LogP | 6.18 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.548 |
| Hazard Codes | Xi |
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| 12-Hydroxyabieta-8,12-diene-11,14-dione |
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