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  • BioBioPha
  • China
  • Product Name: Torilin
  • Price: ¥4500.0/5mg
  • Purity: 97.0%
  • Stocking Period: 10 Day
  • Contact: Xueping-Zheng

13018-10-5

13018-10-5 structure
13018-10-5 structure
  • Name: torilin
  • Chemical Name: [(5S,6R,8S,8aR)-5-(2-acetyloxypropan-2-yl)-3,8-dimethyl-2-oxo-4,5,6,7,8,8a-hexahydro-1H-azulen-6-yl] (Z)-2-methylbut-2-enoate
  • CAS Number: 13018-10-5
  • Molecular Formula: C22H32O5
  • Molecular Weight: 376.49
  • Catalog: Natural product Sesquiter
  • Create Date: 2016-11-02 16:59:18
  • Modify Date: 2024-01-11 19:10:10
  • Torilin is a sesquiterpene with antimicrobial, anticancer, and anti-inflammatory properties. Torilin inhibits LPS-induced NO release, as well as inhibiting iNOS, PGE2, COX-2, NF-α, IL-1β, IL-6, and GM-CSF. Torilin suppresses NF-kB and AP-1 translocation, inhibits TAK1 kinase activation. Subsequently results suppression of MAPK-mediated JNK, p38, ERK1/2, and AP-1 (ATF-2 and c-jun) activation and IKK-mediated I-κBα degradation, p65/p50 activation, and translocation[1].

Name [(5S,6R,8S,8aR)-5-(2-acetyloxypropan-2-yl)-3,8-dimethyl-2-oxo-4,5,6,7,8,8a-hexahydro-1H-azulen-6-yl] (Z)-2-methylbut-2-enoate
Synonyms 2-Butenoic acid, 2-methyl-, (3aR,4S,6R,7S)-7-[1-(acetyloxy)-1-methylethyl]-2,3,3a,4,5,6,7,8-octahydro-1,4-dimethyl-2-oxo-6-azulenyl ester, (2Z)-
8-angeloyl-11-acetyl-8,11-dihydroxy-4-guaien-3-one
(5S,6R,8S,8aR)-5-(2-Acetoxy-2-propanyl)-3,8-dimethyl-2-oxo-1,2,4,5,6,7,8,8a-octahydro-6-azulenyl (2Z)-2-methyl-2-butenoate
torilin
11-acetoxy-8-angeloyl-4-guaien-3-one
Description Torilin is a sesquiterpene with antimicrobial, anticancer, and anti-inflammatory properties. Torilin inhibits LPS-induced NO release, as well as inhibiting iNOS, PGE2, COX-2, NF-α, IL-1β, IL-6, and GM-CSF. Torilin suppresses NF-kB and AP-1 translocation, inhibits TAK1 kinase activation. Subsequently results suppression of MAPK-mediated JNK, p38, ERK1/2, and AP-1 (ATF-2 and c-jun) activation and IKK-mediated I-κBα degradation, p65/p50 activation, and translocation[1].
Related Catalog
References

[1]. Endale M, et al. Torilin Inhibits Inflammation by Limiting TAK1-Mediated MAP Kinase and NF-κB Activation. Mediators Inflamm. 2017;2017:7250968.  

Density 1.1±0.1 g/cm3
Boiling Point 469.2±45.0 °C at 760 mmHg
Melting Point 78-79℃ (methanol )
Molecular Formula C22H32O5
Molecular Weight 376.49
Flash Point 201.0±28.8 °C
Exact Mass 376.224976
PSA 69.67000
LogP 4.23
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.508
Hazard Codes Xi