101020-89-7
101020-89-7 structure
- Name: Artemisitene
- Chemical Name: Artemisitene
- CAS Number: 101020-89-7
- Molecular Formula: C15H20O5
- Molecular Weight: 280.32
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2018-09-11 20:20:27
- Modify Date: 2024-01-03 11:35:29
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Artemisitene, a natural derivative of Artemisinin, is a Nrf2 activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability[1][2].
| Name | Artemisitene |
|---|---|
| Synonyms | artemisitene (methyl artemisinin) |
| Description | Artemisitene, a natural derivative of Artemisinin, is a Nrf2 activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Artemisitene selectively induces DNA double-stranded breaks (DSBs) and apoptosis in various human cancer cells by suppressing the expression of topoisomerases in human cancer cells. Artemisitene selectively destabilizes c-Myc in human cancer cells by promoting the ubiquitination of c-Myc through the specific induction of the c-Myc E3 ligase NEDD4[2]. |
| In Vivo | In Nrf2 wild-type mice, systemic administration of Artemisitene (5-10 mg/kg; i.p.) strongly inhibits bleomycin-induced lung damage[1]. |
| References |
| Melting Point | 160-162°C (lit.) |
|---|---|
| Molecular Formula | C15H20O5 |
| Molecular Weight | 280.32 |
| Exact Mass | 280.13100 |
| PSA | 53.99000 |
| LogP | 2.31500 |
| Vapour Pressure | 3.52E-07mmHg at 25°C |
| Storage condition | 2-8°C |
| Hazard Codes | Xi |
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