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101020-89-7

101020-89-7 structure
101020-89-7 structure
  • Name: Artemisitene
  • Chemical Name: Artemisitene
  • CAS Number: 101020-89-7
  • Molecular Formula: C15H20O5
  • Molecular Weight: 280.32
  • Catalog: Signaling Pathways Apoptosis Apoptosis
  • Create Date: 2018-09-11 20:20:27
  • Modify Date: 2025-08-28 16:56:07
  • Artemisitene, a natural derivative of Artemisinin, is a Nrf2 activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability[1][2].

Name Artemisitene
Synonyms artemisitene (methyl artemisinin)
Description Artemisitene, a natural derivative of Artemisinin, is a Nrf2 activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability[1][2].
Related Catalog
In Vitro Artemisitene selectively induces DNA double-stranded breaks (DSBs) and apoptosis in various human cancer cells by suppressing the expression of topoisomerases in human cancer cells. Artemisitene selectively destabilizes c-Myc in human cancer cells by promoting the ubiquitination of c-Myc through the specific induction of the c-Myc E3 ligase NEDD4[2].
In Vivo In Nrf2 wild-type mice, systemic administration of Artemisitene (5-10 mg/kg; i.p.) strongly inhibits bleomycin-induced lung damage[1].
References

[1]. Weimin Chen, et al. Artemisitene activates the Nrf2-dependent antioxidant response and protects against bleomycin-induced lung injury. FASEB J. 2016 Jul;30(7):2500-10.

[2]. Jian Chen, et al. Artemisitene suppresses tumorigenesis by inducing DNA damage through deregulating c-Myc-topoisomerase pathway. Oncogene. 2018 Sep;37(37):5079-5087.

Melting Point 160-162°C (lit.)
Molecular Formula C15H20O5
Molecular Weight 280.32
Exact Mass 280.13100
PSA 53.99000
LogP 2.31500
Vapour Pressure 3.52E-07mmHg at 25°C
Storage condition 2-8°C
Hazard Codes Xi
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