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145108-58-3

145108-58-3 structure
145108-58-3 structure
  • Name: Dexmedetomidine hydrochloride
  • Chemical Name: dexmedetomidine hydrochloride
  • CAS Number: 145108-58-3
  • Molecular Formula: C13H17ClN2
  • Molecular Weight: 236.740
  • Catalog: Biochemical Inhibitor Neuronal Signaling Adrenergic Receptor Agonist
  • Create Date: 2018-05-14 08:00:00
  • Modify Date: 2025-08-21 22:51:22
  • Dexmedetomidine Hydrochloride is an agonist of adrenergic alpha-2 receptor, which is used in veterinary medicine for its analgesic and sedative properties.Target: Adrenergic alpha-2 ReceptorDexmedetomidine, acting at alpha(2A) adrenoceptors, must be present during the encoding process to decrease discrete cue fear memory; however, its ability to suppress contextual memory is likely the result of blocking the consolidation process [1]. Dexmedetomidine had no analgesic effects in alpha(2A)-adrenoceptor KO mice [2]. Dexmedetomidine was effective in blocking these sympathomimetic actions of cocaine even in all 7 subjects who were homozygous for the Del322-325 polymorphism in the alpha2C AR, a loss-of-function mutation that is highly enriched in blacks [3].
Name dexmedetomidine hydrochloride
Synonyms 4-[(a-Methyl)-2,3-dimethylbenzyl]imidazole Monohydrochloride
4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride (1:1)
Dexdor
1H-imidazole, 4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-, monohydrochloride
5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole,hydrochloride
MFCD07772269
1H-Imidazole, 4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1)
UNII:BH210P244U
UNII-1018WH7F9I
4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole Monohydrochloride
5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole hydrochloride
Precedex
(S)-4-(1-(2,3-Dimethylphenyl)ethyl)-1H-imidazole Monohydrochloride
1H-Imidazole, 4-[1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1)
Dexmedetomidine HCL
4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride (1:1)
4-((S)-a,2,3-Trimethylbenzyl)imidazole Monohydrochloride
(±)-4-(a,2,3-Trimethylbenzyl)imidazole Monohydrochloride
Dexmedetomidine Hydrochloride
4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazolhydrochlorid
4-[(1S)-1-(2,3-diméthylphényl)éthyl]-1H-imidazole chlorhydrate
Dexmedetomidine HCl
4-(S)-[1-(2,3-DIMETHYLPHENYL)ETHYL]-1 H-IMIDAZOLE MONOHY DROCHLORIDE (DEXMEDETOMIDINE HYDROCHLORIDE)
Dexmedetomidine (hydrochloride)
Description Dexmedetomidine Hydrochloride is an agonist of adrenergic alpha-2 receptor, which is used in veterinary medicine for its analgesic and sedative properties.Target: Adrenergic alpha-2 ReceptorDexmedetomidine, acting at alpha(2A) adrenoceptors, must be present during the encoding process to decrease discrete cue fear memory; however, its ability to suppress contextual memory is likely the result of blocking the consolidation process [1]. Dexmedetomidine had no analgesic effects in alpha(2A)-adrenoceptor KO mice [2]. Dexmedetomidine was effective in blocking these sympathomimetic actions of cocaine even in all 7 subjects who were homozygous for the Del322-325 polymorphism in the alpha2C AR, a loss-of-function mutation that is highly enriched in blacks [3].
Related Catalog
References

[1]. Davies, M.F., et al., Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala. Neuropsychopharmacology, 2004. 29(2): p. 229-39.

[2]. Ozdogan, U.K., et al., The involvement of alpha 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice. Eur J Pharmacol, 2004. 497(2): p. 161-71.

[3]. Menon, D.V., et al., Central sympatholysis as a novel countermeasure for cocaine-induced sympathetic activation and vasoconstriction in humans. J Am Coll Cardiol, 2007. 50(7): p. 626-33.
Boiling Point 381.9ºC at 760 mmHg
Melting Point 153 - 158ºC
Molecular Formula C13H17ClN2
Molecular Weight 236.740
Exact Mass 236.108032
PSA 28.68000
LogP 3.98030
Vapour Pressure 1.08E-05mmHg at 25°C
Storage condition Desiccate at RT
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P301 + P312 + P330-P305 + P351 + P338
Hazard Codes Xn
Risk Phrases 22-36/37/38
Safety Phrases 26-36/37/39
RIDADR NONH for all modes of transport
RTECS NI5156750
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