Name | D-glutamine |
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Synonyms |
UNII-U5JDO2770Z
D-2-Aminoglutaramic acid (2S)-2-((2S)-2-Aminopropanoylamino)-4-carbamoylbutanoic acid ZY1&VMYVQ2VZ &&L-L Form glutaminic acid D-Glutamic acid 5-amide Gln L-Ala-L-Gln glutamine L-Gln Pentanoic acid, 2,5-diamino-5-oxo-, (S)- L-Alanyl-L-glutamine Levoglutamide (S)-5-Amino-2-[(S)-2-aminopropanamido]-5-oxopentanoic acid MFCD00065607 L-Glutamine,L-alanyl 2,5-Diamino-5-oxopentanoic acid, (S)- (2S)-2-amino-4-carbamoylbutanoic acid Alanyl-glutamine,Glutamine-S (2R)-2,5-diamino-5-oxopentanoic acid Ala-Gln L-(+)-Glutamine 2-Aminoglutaramic acid, L- (S)-(+)-Glutamine 5-Hydroxy-5-imino-L-norvaline 2-amino-4-carbamoylbutanoic acid N(2)-L-alanyl-L-glutamine Glutamine-S Alanyl-glutamine L-Norvaline, 5-hydroxy-5-imino- L-Glutamic Acid g-Amide H-D-Gln-OH L-Glutamic acid γ-amide N-L-alanyl-L-glutamine L-Glutamine, N2-L-alanyl- L-Glutamine l-alanyl-l-glutamin l-(+)-glutamic acid-5-amide L-Glutamic acid 5-amide H-Ala-Gln-OH GLUTAMINE, L- (2S)-5-Amino-2-{[(2S)-2-aminopropanoyl]amino}-5-oxopentanoic acid L-Glutamine, L-alanyl- S(+)-Glutamic acid 5-amide |
Description | D-Glutamine is a cell-permeable D type stereoisomer of Glutamine. |
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Related Catalog | |
In Vitro | Glutamine is a key amino acid in the central nervous system (CNS), playing an important role in the glutamate/GABA-Glutamine cycle (GGC). In the GGC,Glutamine is transferred from astrocytes to neurons, where it will replenish the inhibitory and excitatory neurotransmitter pools[1]. D-Glutamine has been used to study its role in conferring protection against acetaldehyde-induced disruption of barrier function in Caco-2 cell monolayer. Role of L-Glutamine in the protection of intestinal epithelium from acetaldehyde-induced disruption of barrier function is evaluated in Caco-2 cell monolayer. L-Glutamine reduced the acetaldehyde-induced decrease in transepithelilal electrical resistance and increase in permeability to inulin and lipopolysaccharide in a time- and dose-dependent manner; D-Glutamine, L-aspargine, L-arginine, L-lysine, or L-alanine produced no significant protection. D-Glutamine also fails to influence the acetaldehyde-induced decrease in TER and increase in inulin flux. D-Glutamine or glutaminase inhibitor by themselves did not influence TER or inulin flux in control or acetaldehyde-treated cell monolayers. Lack of effect of D-Glutamine in protection from acetaldehyde indicates that the L-Glutamine-mediated protection is stereospecific[2]. |
Cell Assay | Effect of D-Glutamine and glutaminase inhibitor on acetaldehyde-induced permeability. Caco-2 cell monolayers are incubated for 4 h without or with acetaldehyde (600 μM) and L-Glutamine or D-Glutamine (2 mM) in the absence or presence of 6-diazo-5-oxo-L-norleucine (DON). Transepithelial electrical resistance (TER) and FITC-inulin flux are measured. Values are means±SE (n=6)[2]. |
References |
Density | 1.5±0.1 g/cm3 |
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Boiling Point | 353.5±52.0 °C at 760 mmHg |
Molecular Formula | C5H10N2O3 |
Molecular Weight | 146.145 |
Flash Point | 167.6±30.7 °C |
Exact Mass | 146.069138 |
PSA | 106.41000 |
LogP | -1.28 |
Vapour Pressure | 0.0±1.8 mmHg at 25°C |
Index of Refraction | 1.564 |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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Hazard Codes | Xi:Irritant; |
Risk Phrases | R36/37/38 |
Safety Phrases | S26-S36/37/39 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
HS Code | 29241900 |
Precursor 0 | |
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DownStream 2 | |
HS Code | 2924199090 |
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Summary | 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |