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88-58-4

88-58-4 structure
88-58-4 structure
  • Name: 2,5-Di-tert-butylhydroquinone
  • Chemical Name: 2,5-di-tert-butylbenzene-1,4-diol
  • CAS Number: 88-58-4
  • Molecular Formula: C14H22O2
  • Molecular Weight: 222.323
  • Catalog: Biochemical Carbohydrate Monosaccharide
  • Create Date: 2018-07-11 01:09:39
  • Modify Date: 2025-08-20 19:05:09
  • 2,5-Di-tert-butylhydroquinone (DTBHQ), the indirect food additive, regulates the activity of 5-lipoxygenase as well as the activity of COX-2 (IC50=1.8 and 14.1 μM for 5-LO and COX-2, respectively) [1].
Name 2,5-di-tert-butylbenzene-1,4-diol
Synonyms 2,5-Bis(2-methyl-2-propanyl)-1,4-benzenediol
MFCD00008825
2,5-TBHQ
EINECS 201-841-8
1,4-Benzenediol, 2,5-bis(1,1-dimethylethyl)-
2,5-Di-tert-Butyl-1,4-hydroquinone (DBHQ)
2,5-di-tert-butylhydroquinone
2,5-Di-tert-butylbenzene-1,4-diol
2,5-DITERT-BUTYLBENZENE-1,4-DIOL
2,5-Di-tert-butyl-1,4-hydroquinone
Description 2,5-Di-tert-butylhydroquinone (DTBHQ), the indirect food additive, regulates the activity of 5-lipoxygenase as well as the activity of COX-2 (IC50=1.8 and 14.1 μM for 5-LO and COX-2, respectively) [1].
Related Catalog
Target

5-LO:1.8 μM (IC50)

COX-2:14.1 μM (IC50)

In Vitro DTBHQ influences arachidonic acid (AA) metabolism in biologically relevant concentrations in vitro[1].
References

[1]. Zsofia Kutil, et al. The influence of the quinone antioxidants tert-butylhydroquinone and 2,5-di-tert-butylhydroquinone on the arachidonic acid metabolism in vitro. Food and Agricultural Immunology. Volume 26, 2015-Issue 4.
Density 1.0±0.1 g/cm3
Boiling Point 334.4±37.0 °C at 760 mmHg
Melting Point 216-218 °C(lit.)
Molecular Formula C14H22O2
Molecular Weight 222.323
Flash Point 151.5±21.1 °C
Exact Mass 222.161987
PSA 40.46000
LogP 4.02
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.520
Storage condition Store at RT
Stability Stable. Incompatible with oxidizing agents.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MX5160000
CHEMICAL NAME :
Hydroquinone, 2,5-di-tert-butyl-
CAS REGISTRY NUMBER :
88-58-4
BEILSTEIN REFERENCE NO. :
2049542
LAST UPDATED :
199707
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C14-H22-O2
MOLECULAR WEIGHT :
222.36
WISWESSER LINE NOTATION :
L6V DVJ BX1&1&1 EX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6426 mg/kg/3W-C
TOXIC EFFECTS :
Blood - change in clotting factors Related to Chronic Data - death
REFERENCE :
JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 109,453,1979 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
134 gm/kg/24W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 12,1341,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7949 No. of Facilities: 155 (estimated) No. of Industries: 8 No. of Occupations: 14 No. of Employees: 14136 (estimated) No. of Female Employees: 6832 (estimated)
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS MX5160000
HS Code 29072900
HS Code 2907299090
Summary 2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%
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