2,5-Di-tert-butylhydroquinone

Modify Date: 2025-08-20 19:05:09

2,5-Di-tert-butylhydroquinone structure	Common Name	2,5-Di-tert-butylhydroquinone
	CAS Number	88-58-4	Molecular Weight	222.323
	Density	1.0±0.1 g/cm3	Boiling Point	334.4±37.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₂₂O₂	Melting Point	216-218 °C(lit.)
	MSDS	Chinese USA	Flash Point	151.5±21.1 °C
	Symbol	GHS07	Signal Word	Warning

Use of 2,5-Di-tert-butylhydroquinone

2,5-Di-tert-butylhydroquinone (DTBHQ), the indirect food additive, regulates the activity of 5-lipoxygenase as well as the activity of COX-2 (IC50=1.8 and 14.1 μM for 5-LO and COX-2, respectively) [1].

Name	2,5-di-tert-butylbenzene-1,4-diol
Synonym	More Synonyms

Description	2,5-Di-tert-butylhydroquinone (DTBHQ), the indirect food additive, regulates the activity of 5-lipoxygenase as well as the activity of COX-2 (IC50=1.8 and 14.1 μM for 5-LO and COX-2, respectively) [1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase Signaling Pathways >> Immunology/Inflammation >> COX
Target	5-LO:1.8 μM (IC50) COX-2:14.1 μM (IC50)
In Vitro	DTBHQ influences arachidonic acid (AA) metabolism in biologically relevant concentrations in vitro[1].
References	[1]. Zsofia Kutil, et al. The influence of the quinone antioxidants tert-butylhydroquinone and 2,5-di-tert-butylhydroquinone on the arachidonic acid metabolism in vitro. Food and Agricultural Immunology. Volume 26, 2015-Issue 4.

Density	1.0±0.1 g/cm3
Boiling Point	334.4±37.0 °C at 760 mmHg
Melting Point	216-218 °C(lit.)
Molecular Formula	C₁₄H₂₂O₂
Molecular Weight	222.323
Flash Point	151.5±21.1 °C
Exact Mass	222.161987
PSA	40.46000
LogP	4.02
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.520
InChIKey	JZODKRWQWUWGCD-UHFFFAOYSA-N
SMILES	CC(C)(C)c1cc(O)c(C(C)(C)C)cc1O
Storage condition	Store at RT
Stability	Stable. Incompatible with oxidizing agents.

2,5-Di-tert-butylhydroquinone MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MX5160000

CHEMICAL NAME :: Hydroquinone, 2,5-di-tert-butyl-

CAS REGISTRY NUMBER :: 88-58-4

BEILSTEIN REFERENCE NO. :: 2049542

LAST UPDATED :: 199707

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C14-H22-O2

MOLECULAR WEIGHT :: 222.36

WISWESSER LINE NOTATION :: L6V DVJ BX1&1&1 EX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6426 mg/kg/3W-C

TOXIC EFFECTS :: Blood - change in clotting factors Related to Chronic Data - death

REFERENCE :: JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 109,453,1979 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 134 gm/kg/24W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 12,1341,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7949 No. of Facilities: 155 (estimated) No. of Industries: 8 No. of Occupations: 14 No. of Employees: 14136 (estimated) No. of Female Employees: 6832 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	MX5160000
HS Code	29072900

Precursor 9
CAS#:2460-77-7 2,5-Di-tert-but... CAS#:123-31-9 Hydroquinone CAS#:115-11-7 Isobutylene CAS#:75-65-0 tert-Butanol
CAS#:24850-33-7 Allyltributyltin CAS#:507-19-7 2-Bromo-2-methy... CAS#:1634-04-4 Methyl tert-but... CAS#:124700-28-3 2,5-Di-tert-but...
CAS#:507-20-0 tert-butyl chloride
DownStream 10
CAS#:1991-52-2 2,5-DI-TERT-BUT... CAS#:7323-63-9 1,4-Di-tert-but... CAS#:103858-52-2 Ethyl 4-bromo-1... CAS#:2460-77-7 2,5-Di-tert-but...
CAS#:122-37-2 4-Hydroxydiphen... CAS#:23803-85-2 2-hydroxy-3,6-d... CAS#:124700-28-3 2,5-Di-tert-but... CAS#:122-39-4 Diphenylamine
CAS#:900-02-7 1,4-Benzenediol... CAS#:99758-88-0 1-tert-butyl-2,...

HS Code	2907299090
Summary	2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

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Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: Tocris HTS for Inhibitors of Aerobactin Synthetase lucA
Source: 23265
External Id: IucA Pilot Assay Tocris Library

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482

Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ...
Source: 824
Target: N/A
External Id: P53MS837

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898

Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4303805

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2,5-Bis(2-methyl-2-propanyl)-1,4-benzenediol

MFCD00008825

2,5-TBHQ

EINECS 201-841-8

2,5-Di-tert-Butyl-1,4-hydroquinone (DBHQ)

2,5-di-tert-butylhydroquinone

2,5-Di-tert-butylbenzene-1,4-diol

2,5-DITERT-BUTYLBENZENE-1,4-DIOL

2,5-Di-tert-butyl-1,4-hydroquinone

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 2,5-Di-tert-butylhydroquinone
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Dayang Chem (Hangzhou) Co., Ltd.
China
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 2,5-Di-tert-butylhydroquinone
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Purity: 98.0%
Delivery: 2 Day
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: 2,5-Di-tert-butylhydroquinone ,88-58-4
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Purity: 99.0%
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Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: 2,5-Di-tert-butylhydroquinone
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

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Price: ￥550/10 mM * 1 mL in DMSO

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