252916-76-0

252916-76-0 structure

Name: CHIR-98023
Chemical Name: N'-[4-(2,4-dichlorophenyl)-5-(1H-imidazol-2-yl)pyrimidin-2-yl]-N-(5-nitropyridin-2-yl)ethane-1,2-diamine
CAS Number: 252916-76-0
Molecular Formula: C₂₀H₁₆Cl₂N₈O₂
Molecular Weight: 471.29900
Create Date: 2016-11-22 12:54:12
Modify Date: 2024-01-10 12:39:07
CHIR-98023 is a potent, selective and reversible inhibitor of GSK3, with IC50s of 10 nM and 6.7 nM for GSK3α and GSK3β, respectively. CHIR-98023 can improve insulin action and glucose metabolism[1][2].

Name	N'-[4-(2,4-dichlorophenyl)-5-(1H-imidazol-2-yl)pyrimidin-2-yl]-N-(5-nitropyridin-2-yl)ethane-1,2-diamine
Synonyms	unii-cmq1l0e91y chir-837

Description	CHIR-98023 is a potent, selective and reversible inhibitor of GSK3, with IC50s of 10 nM and 6.7 nM for GSK3α and GSK3β, respectively. CHIR-98023 can improve insulin action and glucose metabolism[1][2].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Research Areas >> Metabolic Disease Research Areas >> Neurological Disease Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
Target	GSK3α:10 nM (IC50) GSK3β:6.7 nM (IC50)
References	[1]. Cline GW, et, al. Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats. Diabetes. 2002 Oct;51(10):2903-10. [2]. Hu M, et, al. Role of GSK-3beta activation and alpha7 nAChRs in Abeta(1-42)-induced tau phosphorylation in PC12 cells. J Neurochem. 2008 Aug;106(3):1371-7.