Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Ethyl 3,4-dihydroxybenzoate
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

BioBioPha
China
Product Name: Ethyl 3,4-dihydroxybenzoate
Price: ￥Inquiry/5mg
Purity: 98.0%
Stocking Period: 10 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Ethyl 3,4-dihydroxybenzoate
Price: ￥78.0/5g ￥238.0/25g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Ethyl 3,4-dihydroxybenzoate
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Ethyl 3,4-dihydroxybenzoate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

3943-89-3

3943-89-3 structure

Name: Ethyl 3,4-dihydroxybenzoate
Chemical Name: Ethyl 3,4-dihydroxybenzoate
CAS Number: 3943-89-3
Molecular Formula: C₉H₁₀O₄
Molecular Weight: 182.173
Catalog: Chemical reagent Organic reagent Ester Ethyl ester compound
Create Date: 2018-08-01 15:35:25
Modify Date: 2024-01-02 20:06:16
Ethyl 3,4-dihydroxybenzoate (Ethyl protocatechuate), an antioxidant, is a prolyl-hydroxylase inhibitor found in the testa of peanut seeds. Ethyl 3,4-dihydroxybenzoate protects myocardium by activating NO synthase and generating mitochondrial ROS. Ethyl 3,4-dihydroxybenzoate induces cell autophagy and apoptosis in ESCC cells. Ethyl 3,4-dihydroxybenzoate is a collagen synthesis inhibitor and has a bone protecting-effect[1][2][3][4].

Name	Ethyl 3,4-dihydroxybenzoate
Synonyms	3,4-dihydroxybenzoic acid ethyl ether Ethyl-3,4-dihydroxybenzoate Benzoic acid, 3,4-dihydroxy-, ethyl ester Ethyl protocatechuate EDHB 3,4-Dihydroxybenzoic acid ethyl ester EINECS 223-529-0 Benzoic acid, 3,4-dihydroxy-, ethyl ester (9CI) Protocatechuic acid ethyl ester MFCD00002199 Ethyl 3,4-dihydroxybenzoate

Description	Ethyl 3,4-dihydroxybenzoate (Ethyl protocatechuate), an antioxidant, is a prolyl-hydroxylase inhibitor found in the testa of peanut seeds. Ethyl 3,4-dihydroxybenzoate protects myocardium by activating NO synthase and generating mitochondrial ROS. Ethyl 3,4-dihydroxybenzoate induces cell autophagy and apoptosis in ESCC cells. Ethyl 3,4-dihydroxybenzoate is a collagen synthesis inhibitor and has a bone protecting-effect[1][2][3][4].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> NO Synthase Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase Research Areas >> Metabolic Disease
References	[1]. Bo Han, et al. A prolyl-hydroxylase inhibitor, ethyl-3,4-dihydroxybenzoate, induces cell autophagy and apoptosis in esophageal squamous cell carcinoma cells via up-regulation of BNIP3 and N-myc downstream-regulated gene-1. PLoS One. 2014 Sep 18;9(9):e107204. [2]. Sebastian Philipp, et al. Desferoxamine and ethyl-3,4-dihydroxybenzoate protect myocardium by activating NOS and generating mitochondrial ROS. Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H450-7. [3]. Byeong-Ju Kwon, et al. Ethyl-3,4-dihydroxybenzoate with a dual function of induction of osteogenic differentiation and inhibition of osteoclast differentiation for bone tissue engineering. Tissue Eng Part A. 2014 Nov;20(21-22):2975-84. [4]. D Nandan, et al. Ethyl-3,4-dihydroxybenzoate inhibits myoblast differentiation: evidence for an essential role of collagen. J Cell Biol. 1990 May;110(5):1673-9.

Density	1.3±0.1 g/cm3
Boiling Point	358.1±22.0 °C at 760 mmHg
Melting Point	132-134 °C(lit.)
Molecular Formula	C₉H₁₀O₄
Molecular Weight	182.173
Flash Point	147.0±15.8 °C
Exact Mass	182.057907
PSA	66.76000
LogP	2.22
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.574

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2918290000

99-50-3

64-17-5

~99%

3943-89-3

Literature: Rey, Jimena; Garcia, Felix Clemente; Garcia, Jose Miguel Reactive and Functional Polymers, 2011 , vol. 71, # 9 p. 948 - 957

1344113-41-2

~78%

3943-89-3

Literature: Huang, Chunhui; Ghavtadze, Nugzar; Chattopadhyay, Buddhadeb; Gevorgyan, Vladimir Journal of the American Chemical Society, 2011 , vol. 133, # 44 p. 17630 - 17633

20986-39-4

~90%

3943-89-3

Literature: Huang, Wei-Bin; Guo, Ying; Jiang, Jian-An; Pan, Xian-Dao; Liao, Dao-Hua; Ji, Ya-Fei Synlett, 2013 , vol. 24, # 6 art. no. ST-2013-W0052-L, p. 741 - 746

120-47-8

3943-89-3

Literature: Huang, Chunhui; Ghavtadze, Nugzar; Chattopadhyay, Buddhadeb; Gevorgyan, Vladimir Journal of the American Chemical Society, 2011 , vol. 133, # 44 p. 17630 - 17633

7647-01-0

99-50-3

64-17-5

3943-89-3

Literature: Matsmoto Chemische Berichte, 1878 , vol. 11, p. 133

Precursor 5
99-50-3 64-17-5 20986-39-4 120-47-8
7647-01-0
DownStream 10
476168-17-9 3943-77-9 39635-11-5 1486-54-0
148527-38-2 39270-39-8 180678-33-5 179688-14-3
99-50-3 20825-87-0

HS Code	2918290000
Summary	HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

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