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3943-89-3

3943-89-3 structure
3943-89-3 structure
  • Name: Ethyl 3,4-dihydroxybenzoate
  • Chemical Name: Ethyl 3,4-dihydroxybenzoate
  • CAS Number: 3943-89-3
  • Molecular Formula: C9H10O4
  • Molecular Weight: 182.173
  • Catalog: Chemical reagent Organic reagent Ester Ethyl ester compound
  • Create Date: 2018-08-01 15:35:25
  • Modify Date: 2025-08-20 16:31:39
  • Ethyl 3,4-dihydroxybenzoate (Ethyl protocatechuate), an antioxidant, is a prolyl-hydroxylase inhibitor found in the testa of peanut seeds. Ethyl 3,4-dihydroxybenzoate protects myocardium by activating NO synthase and generating mitochondrial ROS. Ethyl 3,4-dihydroxybenzoate induces cell autophagy and apoptosis in ESCC cells. Ethyl 3,4-dihydroxybenzoate is a collagen synthesis inhibitor and has a bone protecting-effect[1][2][3][4].
Name Ethyl 3,4-dihydroxybenzoate
Synonyms 3,4-dihydroxybenzoic acid ethyl ether
Ethyl-3,4-dihydroxybenzoate
Benzoic acid, 3,4-dihydroxy-, ethyl ester
Ethyl protocatechuate
EDHB
3,4-Dihydroxybenzoic acid ethyl ester
EINECS 223-529-0
Benzoic acid, 3,4-dihydroxy-, ethyl ester (9CI)
Protocatechuic acid ethyl ester
MFCD00002199
Ethyl 3,4-dihydroxybenzoate
Description Ethyl 3,4-dihydroxybenzoate (Ethyl protocatechuate), an antioxidant, is a prolyl-hydroxylase inhibitor found in the testa of peanut seeds. Ethyl 3,4-dihydroxybenzoate protects myocardium by activating NO synthase and generating mitochondrial ROS. Ethyl 3,4-dihydroxybenzoate induces cell autophagy and apoptosis in ESCC cells. Ethyl 3,4-dihydroxybenzoate is a collagen synthesis inhibitor and has a bone protecting-effect[1][2][3][4].
Related Catalog
References

[1]. Bo Han, et al. A prolyl-hydroxylase inhibitor, ethyl-3,4-dihydroxybenzoate, induces cell autophagy and apoptosis in esophageal squamous cell carcinoma cells via up-regulation of BNIP3 and N-myc downstream-regulated gene-1. PLoS One. 2014 Sep 18;9(9):e107204.

[2]. Sebastian Philipp, et al. Desferoxamine and ethyl-3,4-dihydroxybenzoate protect myocardium by activating NOS and generating mitochondrial ROS. Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H450-7.

[3]. Byeong-Ju Kwon, et al. Ethyl-3,4-dihydroxybenzoate with a dual function of induction of osteogenic differentiation and inhibition of osteoclast differentiation for bone tissue engineering. Tissue Eng Part A. 2014 Nov;20(21-22):2975-84.

[4]. D Nandan, et al. Ethyl-3,4-dihydroxybenzoate inhibits myoblast differentiation: evidence for an essential role of collagen. J Cell Biol. 1990 May;110(5):1673-9.
Density 1.3±0.1 g/cm3
Boiling Point 358.1±22.0 °C at 760 mmHg
Melting Point 132-134 °C(lit.)
Molecular Formula C9H10O4
Molecular Weight 182.173
Flash Point 147.0±15.8 °C
Exact Mass 182.057907
PSA 66.76000
LogP 2.22
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.574
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26-S36-S37/39
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2918290000
HS Code 2918290000
Summary HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%
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