57396-78-8

57396-78-8 structure

Name: Oroxin A
Chemical Name: 5,6-Dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl β-D-glucopyranoside
CAS Number: 57396-78-8
Molecular Formula: C₂₁H₂₀O₁₀
Molecular Weight: 432.378
Catalog: Signaling Pathways Cell Cycle/DNA Damage PARP
Create Date: 2018-07-25 22:13:37
Modify Date: 2024-01-04 19:52:36
Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE), activates peroxisome proliferator-activated receptor γ (PPARγ) by docking into the PPARγ protein ligand-binding domain. Oroxin A exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity[1]. Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence[2].

Name	5,6-Dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl β-D-glucopyranoside
Synonyms	5,6-dihydroxyflavone-7-glucoside B-Aethyl-boracycloheptan 5,6-Dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl β-D-glucopyranoside 1-ethyl-borepane 4H-1-Benzopyran-4-one, 7-(β-D-glucopyranosyloxy)-5,6-dihydroxy-2-phenyl- baicalein-7-O-glucoside Borepane,1-ethyl Baicalein 7-b-D-glucopyranoside Oroxin A

Description	Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE), activates peroxisome proliferator-activated receptor γ (PPARγ) by docking into the PPARγ protein ligand-binding domain. Oroxin A exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity[1]. Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence[2].
Related Catalog	Signaling Pathways >> Epigenetics >> PARP Research Areas >> Metabolic Disease Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
In Vitro	Oroxin A (0.5- 100 μM; 24 hours) significantly increases the PPARγ transcription level and exhibits the strongest activation with 50 μM in HEK-293t cells[1].
References	[1]. Sun W, et al. Oroxin A from Oroxylum indicum prevents the progression from prediabetes to diabetes in streptozotocin and high-fat diet induced mice. Phytomedicine. 2018 Jan 1;38:24-34. [2]. He J, et al. Oroxin A inhibits breast cancer cell growth by inducing robust endoplasmic reticulum stress and senescence. Anticancer Drugs. 2016 Mar;27(3):204-15.

Hazard Codes	N