1353979-43-7

1353979-43-7 structure

Name: NMDAR/TRPM4 inhibitor 8
Chemical Name: N-(3-Bromobenzyl)-N-ethyl-1,2-ethanediamine
CAS Number: 1353979-43-7
Molecular Formula: C₁₁H₁₇BrN₂
Molecular Weight: 257.17
Catalog: Signaling Pathways MAPK/ERK Pathway ERK
Create Date: 2018-07-14 00:02:57
Modify Date: 2024-01-13 05:56:09
NMDAR/TRPM4-IN-2 free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. NMDAR/TRPM4-IN-2 free base shows neuroprotective activity. NMDAR/TRPM4-IN-2 free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. NMDAR/TRPM4-IN-2 free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss[1].

Name	N-(3-Bromobenzyl)-N-ethyl-1,2-ethanediamine
Synonyms	N-(3-Bromobenzyl)-N-ethyl-1,2-ethanediamine 1,2-Ethanediamine, N1-[(3-bromophenyl)methyl]-N1-ethyl- MFCD21096961 NMDAR/TRPM4 inhibitor 8

Description	NMDAR/TRPM4-IN-2 free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. NMDAR/TRPM4-IN-2 free base shows neuroprotective activity. NMDAR/TRPM4-IN-2 free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. NMDAR/TRPM4-IN-2 free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Signaling Pathways >> MAPK/ERK Pathway >> ERK Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Stem Cell/Wnt >> ERK
In Vitro	NMDAR/TRPM4-IN-2 free base (compound 8) (0-10 μM) reduces the interactions of GluN2A and GluN2B with TRPM4 in a dose-dependent manner[1]. NMDAR/TRPM4-IN-2 free base eliminates the CREB shutoff pathway and restores ERK1/2 activation and IEG induction while sparing the synaptic activity-driven, transcription-promoting activities of NMDARs[1].
References	[1]. Yan J, et al. Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants. Science. 2020 Oct 9;370(6513):eaay3302.

Hazard Codes	C