NMDAR/TRPM4 inhibitor 8

Modify Date: 2024-01-13 05:56:09

NMDAR/TRPM4 inhibitor 8 structure	Common Name	NMDAR/TRPM4 inhibitor 8
	CAS Number	1353979-43-7	Molecular Weight	257.17
	Density	1.3±0.1 g/cm3	Boiling Point	300.6±22.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₁₇BrN₂	Melting Point	N/A
	MSDS	N/A	Flash Point	135.6±22.3 °C

Use of NMDAR/TRPM4 inhibitor 8

NMDAR/TRPM4-IN-2 free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. NMDAR/TRPM4-IN-2 free base shows neuroprotective activity. NMDAR/TRPM4-IN-2 free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. NMDAR/TRPM4-IN-2 free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss[1].

Name	N-(3-Bromobenzyl)-N-ethyl-1,2-ethanediamine
Synonym	More Synonyms

Description	NMDAR/TRPM4-IN-2 free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. NMDAR/TRPM4-IN-2 free base shows neuroprotective activity. NMDAR/TRPM4-IN-2 free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. NMDAR/TRPM4-IN-2 free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Signaling Pathways >> MAPK/ERK Pathway >> ERK Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Stem Cell/Wnt >> ERK
In Vitro	NMDAR/TRPM4-IN-2 free base (compound 8) (0-10 μM) reduces the interactions of GluN2A and GluN2B with TRPM4 in a dose-dependent manner[1]. NMDAR/TRPM4-IN-2 free base eliminates the CREB shutoff pathway and restores ERK1/2 activation and IEG induction while sparing the synaptic activity-driven, transcription-promoting activities of NMDARs[1].
References	[1]. Yan J, et al. Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants. Science. 2020 Oct 9;370(6513):eaay3302.

Density	1.3±0.1 g/cm3
Boiling Point	300.6±22.0 °C at 760 mmHg
Molecular Formula	C₁₁H₁₇BrN₂
Molecular Weight	257.17
Flash Point	135.6±22.3 °C
Exact Mass	256.057495
LogP	2.40
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.564