NMDAR/TRPM4 inhibitor 8

Modify Date: 2024-01-13 05:56:09

NMDAR/TRPM4 inhibitor 8 Structure
NMDAR/TRPM4 inhibitor 8 structure
Common Name NMDAR/TRPM4 inhibitor 8
CAS Number 1353979-43-7 Molecular Weight 257.17
Density 1.3±0.1 g/cm3 Boiling Point 300.6±22.0 °C at 760 mmHg
Molecular Formula C11H17BrN2 Melting Point N/A
MSDS N/A Flash Point 135.6±22.3 °C

 Use of NMDAR/TRPM4 inhibitor 8


NMDAR/TRPM4-IN-2 free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. NMDAR/TRPM4-IN-2 free base shows neuroprotective activity. NMDAR/TRPM4-IN-2 free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. NMDAR/TRPM4-IN-2 free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss[1].

 Names

Name N-(3-Bromobenzyl)-N-ethyl-1,2-ethanediamine
Synonym More Synonyms

 NMDAR/TRPM4 inhibitor 8 Biological Activity

Description NMDAR/TRPM4-IN-2 free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. NMDAR/TRPM4-IN-2 free base shows neuroprotective activity. NMDAR/TRPM4-IN-2 free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. NMDAR/TRPM4-IN-2 free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss[1].
Related Catalog
In Vitro NMDAR/TRPM4-IN-2 free base (compound 8) (0-10 μM) reduces the interactions of GluN2A and GluN2B with TRPM4 in a dose-dependent manner[1]. NMDAR/TRPM4-IN-2 free base eliminates the CREB shutoff pathway and restores ERK1/2 activation and IEG induction while sparing the synaptic activity-driven, transcription-promoting activities of NMDARs[1].
References

[1]. Yan J, et al. Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants. Science. 2020 Oct 9;370(6513):eaay3302.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 300.6±22.0 °C at 760 mmHg
Molecular Formula C11H17BrN2
Molecular Weight 257.17
Flash Point 135.6±22.3 °C
Exact Mass 256.057495
LogP 2.40
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.564

 Safety Information

Hazard Codes C

 Synonyms

N-(3-Bromobenzyl)-N-ethyl-1,2-ethanediamine
1,2-Ethanediamine, N1-[(3-bromophenyl)methyl]-N1-ethyl-
MFCD21096961
NMDAR/TRPM4 inhibitor 8
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