1325559-30-5

1325559-30-5 structure
1325559-30-5 structure
  • Name: FlufenaMic acid-13C6
  • Chemical Name: FlufenaMic acid-13C6
  • CAS Number: 1325559-30-5
  • Molecular Formula: C813C6H10F3NO2
  • Molecular Weight: 287.186
  • Catalog: analytical chemistry Standard Analytical standard
  • Create Date: 2018-12-25 12:48:25
  • Modify Date: 2024-01-09 12:31:53
  • Flufenamic acid-13C6 is the 13C6 labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

Name FlufenaMic acid-13C6
Synonyms 2-{[3-(Trifluoromethyl)phenyl]amino}(13C6)benzoic acid
MFCD20036276
Flufenamic acid-(benzoic ring-13C6)
2-(3-Trifluoromethylphenylamino)benzoic-13C6 acid
Benzoic-1,2,3,4,5,6-13C6 acid, 2-[[3-(trifluoromethyl)phenyl]amino]-
Description Flufenamic acid-13C6 is the 13C6 labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

[2]. Guinamard R, et al. Flufenamic acid as an ion channel modulator. Pharmacol Ther. 2013 May;138(2):272-84.

[3]. Pongkorpsakol P, et al. Flufenamic acid protects against intestinal fluid secretion and barrier leakage in a mouse model of Vibrio cholerae infection through NF-κB inhibition and AMPK activation. Eur J Pharmacol. 2017 Mar 5;798:94-104.

[4]. Pongkorpsakol P, et al. Cellular mechanisms underlying the inhibitory effect of flufenamic acid on chloride secretion in human intestinal epithelial cells. J Pharmacol Sci. 2017 Jun;134(2):93-100.

[5]. Pobbati AV, et al. Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy. Structure. 2015;23(11):2076-2086.

Density 1.4±0.1 g/cm3
Molecular Formula C813C6H10F3NO2
Molecular Weight 287.186
Exact Mass 287.086487
Index of Refraction 1.585
Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H315-H318
Precautionary Statements P280-P305 + P351 + P338
Hazard Codes Xi
Risk Phrases 38-41
Safety Phrases 26-39
RIDADR NONH for all modes of transport