187269-40-5
187269-40-5 structure
- Name: Bimosiamose
- Chemical Name: bimosiamose
- CAS Number: 187269-40-5
- Molecular Formula: C46H54O16
- Molecular Weight: 862.911
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2018-10-17 11:20:46
- Modify Date: 2025-08-21 22:00:00
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Bimosiamose is a pan-selectin antagonist, inhibits E-, P-, and L-selectin with IC50s of 88 μM, 20 μM, and 86 μM, respectively, and can be used in the research of inflammatory disease.
| Name | bimosiamose |
|---|---|
| Synonyms |
bimosiamose
[1,1'-Biphenyl]-3-acetic acid, 3',3''-(1,6-hexanediyl)bis[6'-(α-D-mannopyranosyloxy)- 97B5KCW80W 2,2'-{1,6-Hexanediylbis[6'-(α-D-mannopyranosyloxy)-3',3-biphenyldiyl]}diacetic acid 8074 |
| Description | Bimosiamose is a pan-selectin antagonist, inhibits E-, P-, and L-selectin with IC50s of 88 μM, 20 μM, and 86 μM, respectively, and can be used in the research of inflammatory disease. |
|---|---|
| Related Catalog | |
| Target |
IC50: 88 μM (E-selectin), 20 μM (P-selectin), 86 μM (L-selectin)[1] |
| In Vitro | Bimosiamose is a pan-selectin antagonist, inhibits E-, P-, and L-selectin with IC50s of 88 μM, 20 μM, and 86 μM, respectively, and can be used in the research of inflammatory disease[1]. |
| In Vivo | Bimosiamose (25 mg/kg, i.v.) significantly improves the survival in rats subjected to severe hepatic ischemia and reperfusion. Bimosiamose also causes lower ALT enzyme levels and decreases neutrophil infiltration[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 1051.0±65.0 °C at 760 mmHg |
| Molecular Formula | C46H54O16 |
| Molecular Weight | 862.911 |
| Flash Point | 309.7±27.8 °C |
| Exact Mass | 862.341187 |
| LogP | 3.04 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.649 |
| Hazard Codes | Xn |
|---|