199807-33-5

199807-33-5 structure

Name: Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA
Chemical Name: Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA
CAS Number: 199807-33-5
Molecular Formula: C₂₈H₃₉F₃N₈O₉
Molecular Weight: 688.653
Catalog: Peptides
Create Date: 2018-11-18 20:44:02
Modify Date: 2025-08-23 18:44:33
Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) is an inhibitor of integrin αvβ3, with antitumor activity.

Name	Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA
Synonyms	Cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-L-valyl) trifluoroacetate (1:1) Acetic acid, 2,2,2-trifluoro-, compd. with cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-L-valyl) (1:1)

Description	Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) is an inhibitor of integrin αvβ3, with antitumor activity.
Related Catalog	Signaling Pathways >> Cytoskeleton >> Integrin Peptides Research Areas >> Cancer
Target	αvβ3[1]
In Vitro	Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) is an inhibitor of integrin αvβ3. Cyclo(Arg-Gly-Asp-D-Phe-Val) [c(RGDfV); 35 nM] induces disruption of leukemia cell migration and adhesion to leukemia osteoblasts in the 3D and 2D culture systems, affects the leukemia cell cycle and induces apoptosis in leukemia cells[1].
Cell Assay	The osteoblasts are cultured in RPMI 1640 medium for 2 days. MV4-11 cells (1.8×105 cells/mL in the 2D culture system and 1×106 cells/mL in the 3D culture system) are co-cultured with leukemia osteoblasts in RPMI 1640 medium. The experiments used two groups: The experimental group received c(RGDfV) (35 nmol/mL) and the control group received an equal volume of phosphate-buffered saline (PBS) only[1].
References	[1]. Shen ZH, et al. Targeting of the leukemia microenvironment by c(RGDfV) overcomes the resistance to chemotherapy in acute myeloid leukemia in biomimetic polystyrene scaffolds. Oncol Lett. 2016 Nov;12(5):3278-3284.