Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA
Modify Date: 2024-01-07 08:59:12
Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA structure
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Common Name | Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA | ||
|---|---|---|---|---|
| CAS Number | 199807-33-5 | Molecular Weight | 688.653 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H39F3N8O9 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Cyclo(Arg-Gly-Asp-D-Phe-Val) TFACyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) is an inhibitor of integrin αvβ3, with antitumor activity. |
| Name | Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA |
|---|---|
| Synonym | More Synonyms |
| Description | Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) is an inhibitor of integrin αvβ3, with antitumor activity. |
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| Related Catalog | |
| Target |
αvβ3[1] |
| In Vitro | Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) is an inhibitor of integrin αvβ3. Cyclo(Arg-Gly-Asp-D-Phe-Val) [c(RGDfV); 35 nM] induces disruption of leukemia cell migration and adhesion to leukemia osteoblasts in the 3D and 2D culture systems, affects the leukemia cell cycle and induces apoptosis in leukemia cells[1]. |
| Cell Assay | The osteoblasts are cultured in RPMI 1640 medium for 2 days. MV4-11 cells (1.8×105 cells/mL in the 2D culture system and 1×106 cells/mL in the 3D culture system) are co-cultured with leukemia osteoblasts in RPMI 1640 medium. The experiments used two groups: The experimental group received c(RGDfV) (35 nmol/mL) and the control group received an equal volume of phosphate-buffered saline (PBS) only[1]. |
| References |
| Molecular Formula | C28H39F3N8O9 |
|---|---|
| Molecular Weight | 688.653 |
| Exact Mass | 688.279236 |
| Cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-L-valyl) trifluoroacetate (1:1) |
| Acetic acid, 2,2,2-trifluoro-, compd. with cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-L-valyl) (1:1) |