1037589-69-7
1037589-69-7 structure
- Name: PF-05231023
- Chemical Name: PF-05231023
- CAS Number: 1037589-69-7
- Molecular Formula: C26H32N4O8
- Molecular Weight: 528.55
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2019-02-19 15:03:55
- Modify Date: 2024-01-02 12:39:16
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PF-05231023, a long-acting fibroblast growth factor 21 (FGF21) analog, is a FGF21-receptor agonist, suitable for development as a potential treatment for T2DM[1][5].
| Name | PF-05231023 |
|---|
| Description | PF-05231023, a long-acting fibroblast growth factor 21 (FGF21) analog, is a FGF21-receptor agonist, suitable for development as a potential treatment for T2DM[1][5]. |
|---|---|
| Related Catalog | |
| Target |
FGF21-receptor[5]. |
| In Vitro | PF-05231023 is a long-acting fibroblast growth factor 21 (FGF21) analog[2]. |
| In Vivo | Administration of native FGF21 and PF-05231023 ( 3 mg/kg or 10 mg/kg ) improves glucose tolerance and liver insulin sensitivity in Zucker rats[3]. PF-05231023 (10 mg/kg) shows protective effects on Akita retinas. PF-05231023 (10 mg/kg) decreases retinal inflammation in diabetic mice. PF-05231023 (10 mg/kg) administration reduces retinal IL-1β mRNA expression in Akita mice. PF-05231023 (10 mg/kg) administration increases cone-specific arrestin4 expression in Akita mice. PF-05231023 (10 mg/kg) administration restores photoreceptor morphology in Akita mice. PF-05231023 (10 mg/kg) inhibits oxidative-stress-induced inflammation in photoreceptors. PF-05231023 (10 mg/kg) administration decreases the variability of retinal NRF2 levels and shows a trend (non-significant) towards increased NRF2 levels in Akita mice[4]. |
| References |
| Molecular Formula | C26H32N4O8 |
|---|---|
| Molecular Weight | 528.55 |
| Storage condition | 2-8℃ |