1431411-66-3

1431411-66-3 structure
1431411-66-3 structure
  • Name: SIRT-IN-2
  • Chemical Name: SIRT-IN-2
  • CAS Number: 1431411-66-3
  • Molecular Formula: C15H21N5O3S2
  • Molecular Weight: 383.49
  • Catalog: Research Areas Others
  • Create Date: 2019-02-08 12:56:22
  • Modify Date: 2024-07-21 21:29:21
  • SIRT-IN-2 is a potent inhibitor of SIRT1/2/3, with IC50s of 4, 4, 7 μM, respectively.

Name SIRT-IN-2
Description SIRT-IN-2 is a potent inhibitor of SIRT1/2/3, with IC50s of 4, 4, 7 μM, respectively.
Related Catalog
Target

SIRT1:4 nM (IC50)

SIRT2:1 nM (IC50)

SIRT3:7 nM (IC50)

In Vitro SIRT-IN-2 (compound 31) is one of the most potent truncated pan SIRT1/ 2/3 inhibitor, the IC50 values are 4, 4, 7 μM, respectively. SIRT-IN-2 (SIRT1/2/3 pan inhibitor) binds identically in the catalytic active site (RMS=0.29 Å), occupying the nicotinamide C-pocket and acetyl lysine substrate channel[1].
References

[1]. Disch JS, et al. Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem. 2013 May 9;56(9):3666-79.

Molecular Formula C15H21N5O3S2
Molecular Weight 383.49
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