SIRT-IN-2

Modify Date: 2024-07-21 21:29:21

SIRT-IN-2 structure	Common Name	SIRT-IN-2
	CAS Number	1431411-66-3	Molecular Weight	383.49
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₂₁N₅O₃S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SIRT-IN-2

SIRT-IN-2 is a potent inhibitor of SIRT1/2/3, with IC50s of 4, 4, 7 μM, respectively.

Name	SIRT-IN-2

Description	SIRT-IN-2 is a potent inhibitor of SIRT1/2/3, with IC50s of 4, 4, 7 μM, respectively.
Related Catalog	Research Areas >> Others
Target	SIRT1:4 nM (IC50) SIRT2:1 nM (IC50) SIRT3:7 nM (IC50)
In Vitro	SIRT-IN-2 (compound 31) is one of the most potent truncated pan SIRT1/ 2/3 inhibitor, the IC50 values are 4, 4, 7 μM, respectively. SIRT-IN-2 (SIRT1/2/3 pan inhibitor) binds identically in the catalytic active site (RMS=0.29 Å), occupying the nicotinamide C-pocket and acetyl lysine substrate channel[1].
References	[1]. Disch JS, et al. Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem. 2013 May 9;56(9):3666-79.

Molecular Formula	C₁₅H₂₁N₅O₃S₂
Molecular Weight	383.49

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: SIRT-IN-2
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Purity: 98.0%
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