1779493-12-7
1779493-12-7 structure
- Name: Tyk2-IN-3
- Chemical Name: Tyk2-IN-3
- CAS Number: 1779493-12-7
- Molecular Formula: C25H24N6O3S2
- Molecular Weight: 520.63
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2019-02-09 20:31:02
- Modify Date: 2024-01-10 18:09:20
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Tyk2-IN-3 is a Tyk2 pseudokinase inhibitor, with an IC50 of 485 nM.
| Name | Tyk2-IN-3 |
|---|
| Description | Tyk2-IN-3 is a Tyk2 pseudokinase inhibitor, with an IC50 of 485 nM. |
|---|---|
| Related Catalog | |
| Target |
Tyk2:485 nM (IC50) |
| In Vivo | Tyk2-IN-3 (compound 1) is very potent against the Tyk2 pseudokinase (99% inhibition at 1 μM) but lacks potency against all other kinases in the kinome assay panel except IKK (96% inhibition) and the JAK1 pseudokinase domain (99% inhibition at 1 μM). No evidence of binding to the catalytic domain of Tyk2 or any other JAK family kinase is evident at 1 μM, and subsequent enzymatic assays confirm the lack of activity against purified catalytic domains (IC50>>2 μM). The pseudokinase domains of JAK2 and JAK3 are not part of the kinome screening panel. In the IL-23-stimulated kit225 T cell assay, Tyk2-IN-3 inhibits the stimulated response with an IC50 of 485±143 nM (n=3)[1]. |
| References |
| Molecular Formula | C25H24N6O3S2 |
|---|---|
| Molecular Weight | 520.63 |