1485066-18-9
1485066-18-9 structure
- Name: γ-secretase modulator 14a
- Chemical Name: N-(4-Fluorophenyl)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-4,5,6,7-tetrahydro-1,2-benzoxazol-7-amine
- CAS Number: 1485066-18-9
- Molecular Formula: C24H23FN4O2
- Molecular Weight: 418.463
- Create Date: 2020-01-12 10:45:50
- Modify Date: 2024-01-18 23:24:38
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A potent, selective, orally active γ-secretase modulator with Aβ42 IC50 of 39 nM; shows good to excellent selectivity for the reduction of Aβ42 in the cellular assays; significantly reduces Aβ42 in the CNS compartment in vivo in nontransgenic rat models.
| Name | N-(4-Fluorophenyl)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-4,5,6,7-tetrahydro-1,2-benzoxazol-7-amine |
|---|---|
| Synonyms |
N-(4-Fluorophenyl)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-4,5,6,7-tetrahydro-1,2-benzoxazol-7-amine
1,2-Benzisoxazol-7-amine, N-(4-fluorophenyl)-4,5,6,7-tetrahydro-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]- |
| Description | A potent, selective, orally active γ-secretase modulator with Aβ42 IC50 of 39 nM; shows good to excellent selectivity for the reduction of Aβ42 in the cellular assays; significantly reduces Aβ42 in the CNS compartment in vivo in nontransgenic rat models. |
|---|---|
| References | References 1. Zhao Z, et al. ACS Med Chem Lett. 2017 Sep 19;8(10):1002-1006. View Related Products by Target γ-secretase |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 648.0±55.0 °C at 760 mmHg |
| Molecular Formula | C24H23FN4O2 |
| Molecular Weight | 418.463 |
| Flash Point | 345.7±31.5 °C |
| Exact Mass | 418.180511 |
| LogP | 4.21 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.656 |