41609-06-7

41609-06-7 structure

Name: CX 4338
Chemical Name: 2-(Benzylamino)-4,4-dimethyl-6-oxo-N-phenyl-1-cyclohexene-1-carbothioamide
CAS Number: 41609-06-7
Molecular Formula: C₂₂H₂₄N₂OS
Molecular Weight: 364.504
Create Date: 2020-01-11 18:30:34
Modify Date: 2024-01-12 10:24:41
CX 4338 (CX4338, CX-4338) is a potent, selective CXCR2 inhibitor that selectively inhibits CXCR2-mediated recruitment of β-arrestin-2 with IC50 of 6.3 uM; shows little to no inhibition of CXCR4-mediated β-arrestin-2 recruitment at 100 uM; inhibits receptor internalization, while enhancing CXCR2-mediated MAPK activation; inhibits CXCL8-induced chemotaxis in CXCR2-overexpressing cells and human neutrophils; significantly reduces neutrophils in bronchoalveolar lavage induced by LPS in mice.

Name	2-(Benzylamino)-4,4-dimethyl-6-oxo-N-phenyl-1-cyclohexene-1-carbothioamide
Synonyms	MFCD00170629 1-Cyclohexene-1-carbothioamide, 4,4-dimethyl-6-oxo-N-phenyl-2-[(phenylmethyl)amino]- 2-(benzylamino)-4,4-dimethyl-6-oxo-N-phenylcyclohex-1-ene-1-carbothioamide 2-(Benzylamino)-4,4-dimethyl-6-oxo-N-phenyl-1-cyclohexene-1-carbothioamide

Description	CX 4338 (CX4338, CX-4338) is a potent, selective CXCR2 inhibitor that selectively inhibits CXCR2-mediated recruitment of β-arrestin-2 with IC50 of 6.3 uM; shows little to no inhibition of CXCR4-mediated β-arrestin-2 recruitment at 100 uM; inhibits receptor internalization, while enhancing CXCR2-mediated MAPK activation; inhibits CXCL8-induced chemotaxis in CXCR2-overexpressing cells and human neutrophils; significantly reduces neutrophils in bronchoalveolar lavage induced by LPS in mice.
References	References 1. Ha H, et al. Br J Pharmacol. 2014 Mar;171(6):1551-65. View Related Products by Target Chemokine Receptor (CCR and CXCR)