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  • DC Chemicals Limited
  • China
  • Product Name: H3B-8800
  • Price: $650.0/10mg $990.0/25mg $1950.0/100mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao


1825302-42-8

1825302-42-8 structure
1825302-42-8 structure
  • Name: H3B-8800
  • Chemical Name: (2S,3S,4E,6S,7R,10R)-7,10-Dihydroxy-3,7-dimethyl-12-oxo-2-[(2E,4E,6R)-6-(2-pyridinyl)-2,4-heptadien-2-yl]oxacyclododec-4-en-6-yl 4-methyl-1-piperazinecarboxylate
  • CAS Number: 1825302-42-8
  • Molecular Formula: C31H45N3O6
  • Molecular Weight: 555.706
  • Create Date: 2020-01-17 10:23:22
  • Modify Date: 2024-01-04 15:07:38
  • H3B-8800 is an orally available splicing modulator that targets spliceosome SF3b complex containing either WTor mutant SF3B1 (binding IC50 of 0.3-2 nM); demonstrates dose-dependent inhibition of both canonical splicing and aberrant splicing induced by mutant SF3B1 in in vitro assays of biochemical splicing, induces lethality in spliceosome-mutant cancer cells. Blood Cancer Phase 1 Clinical

Name (2S,3S,4E,6S,7R,10R)-7,10-Dihydroxy-3,7-dimethyl-12-oxo-2-[(2E,4E,6R)-6-(2-pyridinyl)-2,4-heptadien-2-yl]oxacyclododec-4-en-6-yl 4-methyl-1-piperazinecarboxylate
Synonyms 1-Piperazinecarboxylic acid, 4-methyl-, (2S,3S,4E,6S,7R,10R)-7,10-dihydroxy-3,7-dimethyl-2-[(1E,3E,5R)-1-methyl-5-(2-pyridinyl)-1,3-hexadien-1-yl]-12-oxooxacyclododec-4-en-6-yl ester
(2S,3S,4E,6S,7R,10R)-7,10-Dihydroxy-3,7-dimethyl-12-oxo-2-[(2E,4E,6R)-6-(2-pyridinyl)-2,4-heptadien-2-yl]oxacyclododec-4-en-6-yl 4-methyl-1-piperazinecarboxylate
Description H3B-8800 is an orally available splicing modulator that targets spliceosome SF3b complex containing either WTor mutant SF3B1 (binding IC50 of 0.3-2 nM); demonstrates dose-dependent inhibition of both canonical splicing and aberrant splicing induced by mutant SF3B1 in in vitro assays of biochemical splicing, induces lethality in spliceosome-mutant cancer cells. Blood Cancer Phase 1 Clinical
References References 1. Seiler M, et al. Nat Med. 2018 Feb 19. doi: 10.1038/nm.4493. 2. Finci LI, et al. Genes Dev. 2018 Feb 1;32(3-4):309-320. 3. Cancer Discov. 2018 Mar 2. doi: 10.1158/2159-8290.CD-RW2018-038. View Related Products by Target Spliceosome Blood Cancer
Density 1.2±0.1 g/cm3
Boiling Point 710.6±60.0 °C at 760 mmHg
Molecular Formula C31H45N3O6
Molecular Weight 555.706
Flash Point 383.6±32.9 °C
Exact Mass 555.330811
LogP 2.22
Vapour Pressure 0.0±2.4 mmHg at 25°C
Index of Refraction 1.581