H3B-8800
Modify Date: 2024-01-04 15:07:38
H3B-8800 structure
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Common Name | H3B-8800 | ||
|---|---|---|---|---|
| CAS Number | 1825302-42-8 | Molecular Weight | 555.706 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 710.6±60.0 °C at 760 mmHg | |
| Molecular Formula | C31H45N3O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 383.6±32.9 °C | |
Use of H3B-8800H3B-8800 is an orally available splicing modulator that targets spliceosome SF3b complex containing either WTor mutant SF3B1 (binding IC50 of 0.3-2 nM); demonstrates dose-dependent inhibition of both canonical splicing and aberrant splicing induced by mutant SF3B1 in in vitro assays of biochemical splicing, induces lethality in spliceosome-mutant cancer cells. Blood Cancer Phase 1 Clinical |
| Name | (2S,3S,4E,6S,7R,10R)-7,10-Dihydroxy-3,7-dimethyl-12-oxo-2-[(2E,4E,6R)-6-(2-pyridinyl)-2,4-heptadien-2-yl]oxacyclododec-4-en-6-yl 4-methyl-1-piperazinecarboxylate |
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| Synonym | More Synonyms |
| Description | H3B-8800 is an orally available splicing modulator that targets spliceosome SF3b complex containing either WTor mutant SF3B1 (binding IC50 of 0.3-2 nM); demonstrates dose-dependent inhibition of both canonical splicing and aberrant splicing induced by mutant SF3B1 in in vitro assays of biochemical splicing, induces lethality in spliceosome-mutant cancer cells. Blood Cancer Phase 1 Clinical |
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| References | References 1. Seiler M, et al. Nat Med. 2018 Feb 19. doi: 10.1038/nm.4493. 2. Finci LI, et al. Genes Dev. 2018 Feb 1;32(3-4):309-320. 3. Cancer Discov. 2018 Mar 2. doi: 10.1158/2159-8290.CD-RW2018-038. View Related Products by Target Spliceosome Blood Cancer |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 710.6±60.0 °C at 760 mmHg |
| Molecular Formula | C31H45N3O6 |
| Molecular Weight | 555.706 |
| Flash Point | 383.6±32.9 °C |
| Exact Mass | 555.330811 |
| LogP | 2.22 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.581 |
| 1-Piperazinecarboxylic acid, 4-methyl-, (2S,3S,4E,6S,7R,10R)-7,10-dihydroxy-3,7-dimethyl-2-[(1E,3E,5R)-1-methyl-5-(2-pyridinyl)-1,3-hexadien-1-yl]-12-oxooxacyclododec-4-en-6-yl ester |
| (2S,3S,4E,6S,7R,10R)-7,10-Dihydroxy-3,7-dimethyl-12-oxo-2-[(2E,4E,6R)-6-(2-pyridinyl)-2,4-heptadien-2-yl]oxacyclododec-4-en-6-yl 4-methyl-1-piperazinecarboxylate |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: H3B-8800
- Price: Negotiable
- Purity: 98.21%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: H3B-8800
- Price: $650.0/10mg $990.0/25mg $1950.0/100mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: H3B-8800
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: H3B-8800(H3B8800)
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Delivery: Inquiry
- Contact: Anson
- Email: info@tianfuchem.com
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