865488-53-5
865488-53-5 structure
- Name: DM-NOFD
- Chemical Name: DM-NOFD
- CAS Number: 865488-53-5
- Molecular Formula: C13H15NO5
- Molecular Weight: 265.262
- Create Date: 2020-01-11 20:35:51
- Modify Date: 2024-02-08 09:23:16
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The dimethyl ester of N-oxalyl-d-phenylalanine (NOFD), a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM); also shows lack of in vitro inhibitory activities against a panel of Jumonji-C containing proteins KDM3A, KDM4E, and KDM6B (IC50>20 uM); more efficiently reduces HIF1α CAD hydroxylation.
| Name | DM-NOFD |
|---|---|
| Synonyms |
N-Oxalyl-D-phenylalanine dimethyl ester
N-(2-Methoxy-2-oxoacetyl)-D-phenylalanine methyl ester Dimethyl N-oxalyl-D-phenylalanine DM-NOFD D-Phenylalanine, N-(2-methoxy-1,2-dioxoethyl)-, methyl ester Methyl N-[methoxy(oxo)acetyl]-D-phenylalaninate |
| Description | The dimethyl ester of N-oxalyl-d-phenylalanine (NOFD), a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM); also shows lack of in vitro inhibitory activities against a panel of Jumonji-C containing proteins KDM3A, KDM4E, and KDM6B (IC50>20 uM); more efficiently reduces HIF1α CAD hydroxylation. |
|---|---|
| References | References 1. Chan MC, et al. J Biol Chem. 2016 Sep 23;291(39):20661-73. 2. McDonough MA, et al. J Am Chem Soc. 2005 Jun 1;127(21):7680-1. View Related Products by Target HIF/HIF Prolyl-hydroxylase |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Molecular Formula | C13H15NO5 |
| Molecular Weight | 265.262 |
| Exact Mass | 265.095032 |
| LogP | 1.61 |
| Index of Refraction | 1.518 |