DM-NOFD

Modify Date: 2024-02-08 09:23:16

DM-NOFD structure	Common Name	DM-NOFD
	CAS Number	865488-53-5	Molecular Weight	265.262
	Density	1.2±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₃H₁₅NO₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of DM-NOFD

The dimethyl ester of N-oxalyl-d-phenylalanine (NOFD), a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM); also shows lack of in vitro inhibitory activities against a panel of Jumonji-C containing proteins KDM3A, KDM4E, and KDM6B (IC50>20 uM); more efficiently reduces HIF1α CAD hydroxylation.

Name	DM-NOFD
Synonym	More Synonyms

Description	The dimethyl ester of N-oxalyl-d-phenylalanine (NOFD), a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM); also shows lack of in vitro inhibitory activities against a panel of Jumonji-C containing proteins KDM3A, KDM4E, and KDM6B (IC50>20 uM); more efficiently reduces HIF1α CAD hydroxylation.
References	References 1. Chan MC, et al. J Biol Chem. 2016 Sep 23;291(39):20661-73. 2. McDonough MA, et al. J Am Chem Soc. 2005 Jun 1;127(21):7680-1. View Related Products by Target HIF/HIF Prolyl-hydroxylase