1883333-94-5
1883333-94-5 structure
- Name: GPR4 antagonist 3b
- Chemical Name: GPR4 antagonist 3b
- CAS Number: 1883333-94-5
- Molecular Formula: C31H37N5
- Molecular Weight: 479.672
- Create Date: 2020-01-20 17:30:56
- Modify Date: 2025-09-18 17:06:45
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The first potent and selective proton-sensing GPCR GPR4 antagonist with IC50 of 67 nM, with no activity against TDAG8 and OGR1 (IC50>10 uM); effectively prolongs life in the mouse myocardial infarction model in vivo, and is a very effective tool for investigating the physiologic and pharmacologic roles of GPR4.
| Name | GPR4 antagonist 3b |
|---|
| Description | The first potent and selective proton-sensing GPCR GPR4 antagonist with IC50 of 67 nM, with no activity against TDAG8 and OGR1 (IC50>10 uM); effectively prolongs life in the mouse myocardial infarction model in vivo, and is a very effective tool for investigating the physiologic and pharmacologic roles of GPR4. |
|---|---|
| References | References 1. Fukuda H, et al. ACS Med Chem Lett. 2016 Feb 24;7(5):493-7. 2. Tobo A, et al. PLoS One. 2015 Jun 12;10(6):e0129334. View Related Products by Target Proton-sensing GPCRs |
| Molecular Formula | C31H37N5 |
|---|---|
| Molecular Weight | 479.672 |