GPR4 antagonist 3b
Modify Date: 2024-02-03 02:17:43
GPR4 antagonist 3b structure
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Common Name | GPR4 antagonist 3b | ||
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| CAS Number | 1883333-94-5 | Molecular Weight | 479.672 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C31H37N5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GPR4 antagonist 3bThe first potent and selective proton-sensing GPCR GPR4 antagonist with IC50 of 67 nM, with no activity against TDAG8 and OGR1 (IC50>10 uM); effectively prolongs life in the mouse myocardial infarction model in vivo, and is a very effective tool for investigating the physiologic and pharmacologic roles of GPR4. |
| Name | GPR4 antagonist 3b |
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| Description | The first potent and selective proton-sensing GPCR GPR4 antagonist with IC50 of 67 nM, with no activity against TDAG8 and OGR1 (IC50>10 uM); effectively prolongs life in the mouse myocardial infarction model in vivo, and is a very effective tool for investigating the physiologic and pharmacologic roles of GPR4. |
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| References | References 1. Fukuda H, et al. ACS Med Chem Lett. 2016 Feb 24;7(5):493-7. 2. Tobo A, et al. PLoS One. 2015 Jun 12;10(6):e0129334. View Related Products by Target Proton-sensing GPCRs |
| Molecular Formula | C31H37N5 |
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| Molecular Weight | 479.672 |