1884209-99-7
1884209-99-7 structure
- Name: IACS-4759
- Chemical Name: IACS-4759
- CAS Number: 1884209-99-7
- Molecular Formula: C10H17N3O2
- Molecular Weight: 211.265
- Create Date: 2020-01-20 19:18:56
- Modify Date: 2024-02-17 23:37:19
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IACS-4759 potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.6 nM; shows no off-target kinase activity in a panel of 97 kinases; exhibits excellent cell permeability and good metabolic stability in microsomes; an excellent tool for interrogation of the utility of MTH1 inhibition in the context of oncology.
| Name | IACS-4759 |
|---|
| Description | IACS-4759 potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.6 nM; shows no off-target kinase activity in a panel of 97 kinases; exhibits excellent cell permeability and good metabolic stability in microsomes; an excellent tool for interrogation of the utility of MTH1 inhibition in the context of oncology. |
|---|---|
| References | References 1. Petrocchi A, et al. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1503-7. View Related Products by Target DNA Repair Protein |
| Molecular Formula | C10H17N3O2 |
|---|---|
| Molecular Weight | 211.265 |