IACS-4759
Modify Date: 2024-02-17 23:37:19
IACS-4759 structure
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Common Name | IACS-4759 | ||
|---|---|---|---|---|
| CAS Number | 1884209-99-7 | Molecular Weight | 211.265 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C10H17N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of IACS-4759IACS-4759 potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.6 nM; shows no off-target kinase activity in a panel of 97 kinases; exhibits excellent cell permeability and good metabolic stability in microsomes; an excellent tool for interrogation of the utility of MTH1 inhibition in the context of oncology. |
| Name | IACS-4759 |
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| Description | IACS-4759 potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.6 nM; shows no off-target kinase activity in a panel of 97 kinases; exhibits excellent cell permeability and good metabolic stability in microsomes; an excellent tool for interrogation of the utility of MTH1 inhibition in the context of oncology. |
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| References | References 1. Petrocchi A, et al. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1503-7. View Related Products by Target DNA Repair Protein |
| Molecular Formula | C10H17N3O2 |
|---|---|
| Molecular Weight | 211.265 |