1884209-98-6

1884209-98-6 structure

Name: IACS-4619
Chemical Name: IACS-4619
CAS Number: 1884209-98-6
Molecular Formula: C₁₀H₁₇N₃O
Molecular Weight: 195.266
Create Date: 2020-01-11 16:18:49
Modify Date: 2024-09-10 17:55:48
IACS-4759 potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.2 nM; shows no off-target kinase activity in a panel of 97 kinases; exhibits excellent cell permeability and good metabolic stability in microsomes; an excellent tool for interrogation of the utility of MTH1 inhibition in the context of oncology.

Name	IACS-4619

Description	IACS-4759 potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.2 nM; shows no off-target kinase activity in a panel of 97 kinases; exhibits excellent cell permeability and good metabolic stability in microsomes; an excellent tool for interrogation of the utility of MTH1 inhibition in the context of oncology.
References	References 1. Petrocchi A, et al. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1503-7. View Related Products by Target DNA Repair Protein

Molecular Formula	C₁₀H₁₇N₃O
Molecular Weight	195.266