2100855-80-7
2100855-80-7 structure
- Name: PI3Kα-IN-4h
- Chemical Name: PI3Kα-IN-4h
- CAS Number: 2100855-80-7
- Molecular Formula: C26H25N7O3
- Molecular Weight: 483.532
- Create Date: 2020-01-12 11:00:50
- Modify Date: 2024-04-02 21:04:47
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PI3Kα-IN-1 is a potent, selective, ATP-competitive dual PI3Kα/mTOR inhibitor with IC50 of 0.5/104 nM respectively; displays good selectivity for PI3Kα; demonstrates cytotoxicity in MCF7 cells, reasonable toxicity in MDA-MB-468 cells, good therapeutic index compared to normal skin fibroblasts, and acceptable in vitro ADME properties.
| Name | PI3Kα-IN-4h |
|---|
| Description | PI3Kα-IN-1 is a potent, selective, ATP-competitive dual PI3Kα/mTOR inhibitor with IC50 of 0.5/104 nM respectively; displays good selectivity for PI3Kα; demonstrates cytotoxicity in MCF7 cells, reasonable toxicity in MDA-MB-468 cells, good therapeutic index compared to normal skin fibroblasts, and acceptable in vitro ADME properties. |
|---|---|
| References | References 1. Al-Ashmawy AAK, et al. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3117-3122. View Related Products by Target PI3K |
| Molecular Formula | C26H25N7O3 |
|---|---|
| Molecular Weight | 483.532 |