2101744-13-0
2101744-13-0 structure
- Name: PI3Kα-IN-5
- Chemical Name: PI3Kα-IN-5
- CAS Number: 2101744-13-0
- Molecular Formula: C17H17N9O
- Molecular Weight: 363.385
- Create Date: 2020-01-20 14:48:56
- Modify Date: 2024-04-09 10:44:54
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PI3Kα-IN-5 is a potent, selective PI3Kα inhibitor with enzyme IC50 and cell IC50 of 6 nM and 87 nM respectively, exhibits 100-fold selectivity over PI3Kβ; displays high potency and selectivity, and suitable physiochemical and pharmacokinetic properties for oral administration; shows good inhibition of tumour growth (86% tumour growth inhibition at 50 mg/kg twice daily orally) in the MCF7 xenograft model in mice.
| Name | PI3Kα-IN-5 |
|---|
| Description | PI3Kα-IN-5 is a potent, selective PI3Kα inhibitor with enzyme IC50 and cell IC50 of 6 nM and 87 nM respectively, exhibits 100-fold selectivity over PI3Kβ; displays high potency and selectivity, and suitable physiochemical and pharmacokinetic properties for oral administration; shows good inhibition of tumour growth (86% tumour growth inhibition at 50 mg/kg twice daily orally) in the MCF7 xenograft model in mice. |
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| References | References 1. Barlaam B, et al. Bioorg Med Chem Lett. 2017 Jul 1;27(13):3030-3035. View Related Products by Target PI3K |
| Molecular Formula | C17H17N9O |
|---|---|
| Molecular Weight | 363.385 |