PF-719 dihydrochloride
Modify Date: 2025-09-18 12:47:00
PF-719 dihydrochloride structure
|
Common Name | PF-719 dihydrochloride | ||
|---|---|---|---|---|
| CAS Number | 1404454-02-9 | Molecular Weight | 521.41 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H29Cl2F3N6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PF-719 dihydrochloridePF-719 (PF719) is a potent, selective Pyk2 inhibitor with IC50 of 17 nM, displays 25-fold selectvity over FAK (IC50=469 nM); does not have significant inhibitory effects on recombinant MLCK2, p38, Akt1, or ROCK1, and very little inhibtion at Src family kinases (IC50>5 uM); selectively inhibits tyrosine phosphorylation of Pyk2 at 1 uM, but blocks both Pyk2 and FAK phosphorylation at 2.5 uM in A20 cells; reduces chemoattractant-induced migration of B-2 and MZ B cells. |
| Name | PF-719 dihydrochloride |
|---|
| Description | PF-719 (PF719) is a potent, selective Pyk2 inhibitor with IC50 of 17 nM, displays 25-fold selectvity over FAK (IC50=469 nM); does not have significant inhibitory effects on recombinant MLCK2, p38, Akt1, or ROCK1, and very little inhibtion at Src family kinases (IC50>5 uM); selectively inhibits tyrosine phosphorylation of Pyk2 at 1 uM, but blocks both Pyk2 and FAK phosphorylation at 2.5 uM in A20 cells; reduces chemoattractant-induced migration of B-2 and MZ B cells. |
|---|---|
| References | References 1. Tse KW, et al. Cell Immunol. 2012 Jan-Feb;275(1-2):47-54. View Related Products by Target Focal Adhesion Kinase (FAK) |
| Molecular Formula | C22H29Cl2F3N6O |
|---|---|
| Molecular Weight | 521.41 |
| InChIKey | VLCXBDGNSAGPRB-QZTJIDSGSA-N |
| SMILES | CN(C)C1CCCC1Nc1nc(Nc2ccc(C(=O)NC3CC3)cc2)ncc1C(F)(F)F |